INT148428

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.22
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
synaptic vesicles 2
cerebral cortex 1
vesicle 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 1 99.24 Very High Very High Very High
cerebral cortex 1 98.90 Very High Very High Very High
anesthesia 7 97.06 Very High Very High Very High
isoflurane 2 92.12 High High
Versed 1 88.24 High High
Glutamate receptor 16 79.04 Quite High
agonist 5 77.52 Quite High
Neurotransmitter 18 66.80 Quite High
Hippocampus 4 50.44 Quite High
Multiple sclerosis 3 35.28 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 1 89.20 High High
Poisoning 1 71.84 Quite High
Apoptosis 1 57.76 Quite High
Demyelinating Disease 3 35.28 Quite Low
Depression 5 18.40 Low Low
Disease 12 17.04 Low Low
Shock 6 6.48 Low Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low
Dementia 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
SNAP-25 Binding (levels) of in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
1) Confidence 0.37 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
The visual cortical tissue was harvested on various days (1 day, 1 week, 2 weeks, and 4 weeks) after the injection of BoNT/E solution and subjected to western blot analysis using a monoclonal antibody that recognizes both intact and BoNT/E-cleaved SNAP-25.
SNAP-25 Binding (recognizes) of
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.07 Pain Relevance 0.03
The latter included the ubiquitin-binding factor TAX1BP1 and synaptic vesicle protein SNAP-25.
SNAP-25 Binding (binding) of in synaptic vesicle
3) Confidence 0.11 Published 2010 Journal Frontiers in Molecular Neuroscience Section Abstract Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.08
g of protein) were incubated with syntaxin1/SNAP-25 (2 ?
SNAP-25 Binding (incubated) of
4) Confidence 0.11 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
Interestingly, synaptobrevin in synaptic vesicles does not readily react with syntaxin and SNAP-25 (Hu et al., 2002).
SNAP-25 Binding (syntaxin) of in synaptic vesicles
5) Confidence 0.11 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0.03
Recombinant syntaxin was mixed with an equimolar ratio of SNAP-25 overnight at 4°C to allow formation of syntaxin/SNAP-25 heterodimers.
SNAP-25 Binding (formation) of
6) Confidence 0.10 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
The interaction between synaptic proteasomes and SNAP-25, a key synaptic vesicle protein (DeBello et al., 1995; Montecucco et al., 2005), may provide a mechanism for the proteolytic control of vesicle dynamics.
SNAP-25 Binding (interaction) of in vesicle
7) Confidence 0.09 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0

General Comments

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