INT148429

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
cerebral cortex 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 1 99.62 Very High Very High Very High
cerebral cortex 1 99.28 Very High Very High Very High
anesthesia 5 97.44 Very High Very High Very High
isoflurane 1 92.88 High High
Versed 1 89.00 High High
Neurotransmitter 6 39.60 Quite Low
Glutamate 10 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 1 89.96 High High
Apoptosis 1 58.52 Quite High
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Regulation (modulating) of SNAP-25 in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
1) Confidence 0.27 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53
Thus, membrane-embedded syntaxin/SNAP-25 heterodimers are available for SNARE assembly and sphingosine appears to affect specifically synaptobrevin in lipid membranes.
Regulation (available) of SNAP-25
2) Confidence 0.13 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0

General Comments

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