INT14843

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2011
Negated 9
Speculated 10
Reported most in Body
Documents 301
Total Number 311
Disease Relevance 62.63
Pain Relevance 139.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 32
neuronal 7
Leydig cells 6
oocytes 5
retina 4
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 7901 100.00 Very High Very High Very High
antagonist 1234 100.00 Very High Very High Very High
agonist 1173 100.00 Very High Very High Very High
Pyramidal cell 941 100.00 Very High Very High Very High
Neurotransmitter 934 100.00 Very High Very High Very High
Glutamate 924 100.00 Very High Very High Very High
GABA receptor 466 100.00 Very High Very High Very High
nMDA receptor 242 100.00 Very High Very High Very High
Morphine 230 100.00 Very High Very High Very High
Glutamate receptor 214 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 834 100.00 Very High Very High Very High
Generalized Anxiety Disorder 596 100.00 Very High Very High Very High
Ocular Hypertension 13 100.00 Very High Very High Very High
Stress 148 99.96 Very High Very High Very High
Targeted Disruption 1029 99.88 Very High Very High Very High
Ganglion Cysts 451 99.88 Very High Very High Very High
Respiratory Failure 40 99.88 Very High Very High Very High
Neuropathic Pain 279 99.60 Very High Very High Very High
Anxiety Disorder 420 99.56 Very High Very High Very High
Depression 366 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether gabapentin increased the expression of GABAA receptors, Western blots were stained with antibodies selective for alpha1, alpha2, and alpha5 subunits.
Gene_expression (expression) of GABAA
1) Confidence 0.77 Published 2006 Journal Anesthesiology Section Body Doc Link 16871066 Disease Relevance 0 Pain Relevance 0
Neither gabapentin nor vigabatrin increased the expression of GABAA receptors in the neurons.
Gene_expression (expression) of GABAA in neurons
2) Confidence 0.77 Published 2006 Journal Anesthesiology Section Body Doc Link 16871066 Disease Relevance 0 Pain Relevance 0
GABA(B) receptors are broadly expressed in the nervous system.
Gene_expression (expressed) of GABA in nervous system associated with gaba
3) Confidence 0.76 Published 2004 Journal Genesis Section Abstract Doc Link 15493018 Disease Relevance 0.36 Pain Relevance 0.49
These GABA(B(1)) (-/-) mice no longer synthesize GABA(B(1)) protein and exhibit the expected behavioral abnormalities.
Gene_expression (synthesize) of GABA associated with gaba and congenital anomalies
4) Confidence 0.76 Published 2004 Journal Genesis Section Abstract Doc Link 15493018 Disease Relevance 0.40 Pain Relevance 0.71
Following the harvesting of the cytoplasmic contents of individual GnRH neurons, single cell multiplex RT-PCR experiments demonstrated that GABAA receptor alpha1-5, beta1-3 and gamma2 & 3 subunit transcripts were expressed by both neonatal (postnatal day 5) and juvenile (day 15-20) GnRH neurons in a heterogeneous manner.
Gene_expression (expressed) of GABAA in neurons
5) Confidence 0.75 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.20
METHODS: The effects of propofol and 4-iodopropofol were analyzed on heterologously expressed recombinant human GABAA alpha1beta2gamma2 receptors, evoked population spike amplitudes in rat hippocampal slices, and glutamate release from rat cerebrocortical synaptosomes in vitro.
Gene_expression (expressed) of GABAA in spike
6) Confidence 0.75 Published 2001 Journal Anesthesiology Section Body Doc Link 11465597 Disease Relevance 0 Pain Relevance 0
GABAA receptor alpha6 subunit gene expression marks cerebellar granule cell maturation.
Gene_expression (expression) of GABAA in cerebellar granule cell
7) Confidence 0.75 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9525999 Disease Relevance 0 Pain Relevance 0
The alterations in the expression of several GABAA receptor subunits and that of CB1 may, on the other hand, be of importance for seizure regulation.
Gene_expression (expression) of GABAA associated with convulsion
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.74 Pain Relevance 0.32
At a higher plate temperature (55 degrees C), GABA-transaminase inhibitors produced minimal analgesia but significantly enhanced the analgesic action of baclofen. gamma-Vinyl GABA markedly increased both the peak effect and the duration of analgesia but gamma-acetylenic GABA and amino-oxyacetic acid caused smaller increases.
Gene_expression (produced) of GABA associated with gaba, analgesic and analgesia
9) Confidence 0.74 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7110528 Disease Relevance 0 Pain Relevance 1.72
Although both GABAA and NMDA receptors are expressed in the majority of SCN neurons, postnatal development of their functions has not been analysed.
Gene_expression (expressed) of GABAA in SCN associated with nmda receptor
10) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534969 Disease Relevance 0 Pain Relevance 0.09
Anesthetic actions of GABAA receptors
Gene_expression (receptors) of GABAA
11) Confidence 0.65 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.53
GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity.
Gene_expression (expression) of GABAA in thalamus associated with thalamus and alcohol
12) Confidence 0.65 Published 2007 Journal Alcohol Section Title Doc Link 17521848 Disease Relevance 0.18 Pain Relevance 0.61
Finally, evidence has been shown that a tonic current mediated by GABAA receptors containing the ?
Gene_expression (receptors) of GABAA
13) Confidence 0.65 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.54
Although, GABAA receptors in the VTA does not mediate the increase in accumbal dopamine observed after food consumption induced by ghrelin (Kawahara et al. 2009).
Gene_expression (receptors) of GABAA associated with ventral tegmentum and dopamine
14) Confidence 0.65 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0.05 Pain Relevance 0.72
Haplotype analysis of one of the blocks in the GABA-A receptor ?
Gene_expression (receptor) of GABA-A associated with gaba
15) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC2072938 Disease Relevance 0 Pain Relevance 0.20
GABAA, NMDA and cannabinoid receptor signalling
Gene_expression (signalling) of GABAA associated with cannabinoid receptor
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.60 Pain Relevance 0.22
PREGS at micromolar concentrations has also been shown to modulate the functions of several receptors and channels, namely GABAA receptors, glycine receptors, NMDA receptors, ?
Gene_expression (receptors) of GABAA associated with nmda receptor
17) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2710005 Disease Relevance 0.18 Pain Relevance 0.41
Similarly, deletion of GABAA receptor ?
Gene_expression (deletion) of GABAA receptor
18) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.26 Pain Relevance 0.49
Melatonin, a primary secretory product of pineal gland, is known to produce many of its pharmacological actions via benzodiazepine-gamma-aminobutyric acidA (GABAA)ergic mechanisms.
Gene_expression (produce) of GABAA in pineal gland
19) Confidence 0.64 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15582681 Disease Relevance 0 Pain Relevance 0.66
The inhibitors of GABA-transaminase, amino-oxyacetic acid, gamma-acetylenic GABA and gamma-vinyl GABA, produced analgesia which was much more prolonged than that observed with muscimol, baclofen or morphine.
Gene_expression (produced) of GABA associated with gaba, morphine and analgesia
20) Confidence 0.64 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7110528 Disease Relevance 0 Pain Relevance 1.46

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