INT148446

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 23.19
Pain Relevance 9.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Inhbe)
Anatomy Link Frequency
neurons 6
brain 4
neural 2
quadriceps 1
bars 1
Inhbe (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 805 100.00 Very High Very High Very High
qutenza 6 99.84 Very High Very High Very High
Central nervous system 483 99.48 Very High Very High Very High
Inflammation 1725 99.42 Very High Very High Very High
cINOD 598 98.68 Very High Very High Very High
Inflammatory response 230 97.32 Very High Very High Very High
antagonist 184 96.96 Very High Very High Very High
cytokine 322 95.92 Very High Very High Very High
ischemia 23 95.88 Very High Very High Very High
Pain 2 90.00 High High
Disease Link Frequency Relevance Heat
Injury 232 99.56 Very High Very High Very High
Neurodegenerative Disease 2944 99.50 Very High Very High Very High
INFLAMMATION 2047 99.42 Very High Very High Very High
Coronary Heart Disease 16 99.12 Very High Very High Very High
Gliosis 529 97.64 Very High Very High Very High
Transient Ischemic Attack 23 96.64 Very High Very High Very High
Hypoxia 23 95.36 Very High Very High Very High
Nociception 4 94.28 High High
Death 92 92.48 High High
Pain 4 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological studies revealed that the activin sensitization of capsaicin responses required PKCepsilon signaling, but not PI3K (phosphoinositide 3-kinase), ERK (extracellular signal-regulated protein kinase), PKA, PKCalpha/beta, or Src.
Gene_expression (sensitization) of activin associated with qutenza
1) Confidence 0.11 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077689 Disease Relevance 0.67 Pain Relevance 0.69
Activin receptors were found widely distributed among adult sensory neurons, including those that also express the capsaicin receptor.
Gene_expression (found) of Activin in adult sensory neurons associated with qutenza
2) Confidence 0.11 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077689 Disease Relevance 0.72 Pain Relevance 0.59
A physiologically important question is whether endogenously expressed activin A is required for neurogenesis (beyond its postinjury inhibition of inflammation) in the neurodegenerating brain?
Gene_expression (expressed) of activin in brain associated with inflammation and neurodegenerative disease
3) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.09 Pain Relevance 0.31
However, activin A expression is low in the intact brain.
Gene_expression (expression) of activin in brain
4) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.15
A number of studies have shown that activin A expression is increased in principal neurons in the hippocampus of adult rodents in models of transient cerebral ischemia and hypoxia and also after KA treatment [11–14].
Gene_expression (expression) of activin in neurons associated with transient ischemic attack, hypoxia, ischemia and hippocampus
5) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.98 Pain Relevance 0.26
We confirmed that KA-induced neurodegeneration leads to expression of activin A.
Gene_expression (expression) of activin
6) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.19 Pain Relevance 0.32
Our results therefore demonstrate that activin A, which is expressed by neurons, is capable of inducing neural stem/progenitor cell proliferation, leading to increased neurogenesis, through a potent anti-inflammatory action in vivo (Fig. 7H).
Gene_expression (expressed) of activin in neural associated with inflammation and neurodegenerative disease
7) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.47 Pain Relevance 0.69
In summary, neurogenesis after neurodegeneration requires expression of activin A (Fig. 7H).
Gene_expression (expression) of activin associated with neurodegenerative disease
8) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.14 Pain Relevance 0.48
Regardless, although activin A may not be expressed exclusively by neurons in the CNS, our study suggests that activin A expression by neurons is part of an intrinsic overall centrally derived anti-inflammatory response to excitotoxic neurodegeneration that regulates neurogenesis in the CNS.
Neg (not) Gene_expression (expressed) of activin in neurons associated with inflammatory response, central nervous system and neurodegenerative disease
9) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.16 Pain Relevance 0.52
Regardless, although activin A may not be expressed exclusively by neurons in the CNS, our study suggests that activin A expression by neurons is part of an intrinsic overall centrally derived anti-inflammatory response to excitotoxic neurodegeneration that regulates neurogenesis in the CNS.
Gene_expression (expression) of activin in neurons associated with inflammatory response, central nervous system and neurodegenerative disease
10) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.04 Pain Relevance 0.49
Thus, progression of neurogenesis after neurodegeneration requires the presence of an anti-inflammatory agent, either endogeneously expressed activin A or, in its absence, an exogenously administered anti-inflammatory agent.
Gene_expression (expressed) of activin associated with inflammation and neurodegenerative disease
11) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.16 Pain Relevance 0.37
We show for the first time that this activin A expression is essential for neurogenesis to proceed following neurodegeneration.
Gene_expression (expression) of activin associated with neurodegenerative disease
12) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.61 Pain Relevance 0.13
FS-288 binds to activin A and therefore blocks the activin A that is expressed in the brain from having any effect.
Gene_expression (expressed) of activin in brain
13) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.81 Pain Relevance 0.47
Activin A is, however, expressed more than 48 hours after KA injury (supporting information Table 1) and, as shown in Figures 1 and 2, is required for neurogenesis after neurodegeneration occurs.
Gene_expression (expressed) of Activin associated with injury and neurodegenerative disease
14) Confidence 0.06 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.61 Pain Relevance 0.03
Some studies suggest that ligands in the TGF/activin branch, TGF?
Gene_expression (branch) of activin
15) Confidence 0.06 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.88 Pain Relevance 0.32
The fact that activin A is expressed by neurons raises the possibility of an internal response system, where injured neurons signal for anti-inflammatory action.
Gene_expression (expressed) of activin in internal associated with inflammation
16) Confidence 0.06 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.82 Pain Relevance 0.38
(H): Local activin A expression following injury acts as an anti-inflammatory, inhibiting gliosis and microglial activation while promoting neurogenesis.
Gene_expression (expression) of activin associated with inflammation, injury, neurodegenerative disease and gliosis
17) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.83 Pain Relevance 0.79
However, increased activin A expression from surviving neurons is a potent anti-inflammatory agent that inhibits proliferation and activation of microglia and either directly and/or indirectly inhibits the gliotic response by astrocytes.
Gene_expression (expression) of activin in astrocytes associated with inflammation
18) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.03 Pain Relevance 0.56
Endogenously expressed activin A may directly stimulate neurogenesis after neurodegeneration (because it stimulated neurogenesis directly in the intact brain, Fig. 2).
Gene_expression (expressed) of activin in brain associated with neurodegenerative disease
19) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.17 Pain Relevance 0.34
However, FS-288 administration prevented the subsequent increase in total neuron population observed 42 days after the KA-induced neurodegeneration, suggesting endogenous activin A expression increases total neuron population after KA neurodegeneration.
Gene_expression (expression) of activin in neuron
20) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.28 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox