INT148450

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Inhbe (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 100.00 Very High Very High Very High
Thermal hyperalgesia 4 93.60 High High
Pain 2 76.40 Quite High
Hyperalgesia 2 75.00 Quite High
Root ganglion neuron 2 75.00 Quite High
Stimulus evoked pain 2 64.80 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 93.60 High High
Nociception 4 80.68 Quite High
Pain 4 76.40 Quite High
Ganglion Cysts 2 75.00 Quite High
Injury 2 73.48 Quite High
Hypersensitivity 2 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological studies revealed that the activin sensitization of capsaicin responses required PKCepsilon signaling, but not PI3K (phosphoinositide 3-kinase), ERK (extracellular signal-regulated protein kinase), PKA, PKCalpha/beta, or Src.
Gene_expression (sensitization) of activin Neg (not) Positive_regulation (required) of ERK associated with qutenza
1) Confidence 0.07 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077689 Disease Relevance 0.67 Pain Relevance 0.70
Pharmacological studies revealed that the activin sensitization of capsaicin responses required PKCepsilon signaling, but not PI3K (phosphoinositide 3-kinase), ERK (extracellular signal-regulated protein kinase), PKA, PKCalpha/beta, or Src.
Gene_expression (sensitization) of activin Neg (not) Positive_regulation (required) of extracellular signal-regulated protein kinase associated with qutenza
2) Confidence 0.07 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077689 Disease Relevance 0.68 Pain Relevance 0.71

General Comments

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