INT148456

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.35
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LY96) extracellular region (LY96) plasma membrane (LY96)
Anatomy Link Frequency
MD2 3
macrophages 1
endothelial cells 1
HSCs 1
epithelial cells 1
LY96 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 171 100.00 Very High Very High Very High
fibrosis 54 99.08 Very High Very High Very High
cytokine 204 98.20 Very High Very High Very High
drug abuse 1 98.12 Very High Very High Very High
Pain 5 96.88 Very High Very High Very High
Inflammatory marker 3 94.84 High High
Inflammation 242 92.08 High High
Inflammatory response 86 90.08 High High
tolerance 30 85.52 High High
Glutamate 2 85.16 High High
Disease Link Frequency Relevance Heat
Cirrhosis 183 99.98 Very High Very High Very High
Stroke 1 98.84 Very High Very High Very High
Epilepsy 1 98.52 Very High Very High Very High
Drug Dependence 1 98.12 Very High Very High Very High
Pseudomonas Infection 4 97.96 Very High Very High Very High
Schizophrenia 1 97.64 Very High Very High Very High
Sprains And Strains 7 97.00 Very High Very High Very High
Pain 7 96.88 Very High Very High Very High
Apoptosis 41 96.84 Very High Very High Very High
Cardiovascular Disease 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression and contribution of MD2, CD14, and LBP in limbal and conjunctival epithelial cells
Gene_expression (Expression) of MD2 in epithelial cells
1) Confidence 0.19 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.28 Pain Relevance 0.08
Expression of MD2 (?
Gene_expression (Expression) of MD2 in MD2
2) Confidence 0.19 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.25 Pain Relevance 0.09
in macrophages (RAW264.7) and 293T cells transfected with TLR4 and MD2, and the NF-?
Gene_expression (transfected) of MD2 in macrophages
3) Confidence 0.18 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.09 Pain Relevance 0.18
EDA stimulation of TLR4 is dependent upon co-expression of MD2, a TLR4 accessory protein [48].


Gene_expression (expression) of MD2 in MD2
4) Confidence 0.14 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.38 Pain Relevance 0.24
Activated human HSCs express LPS-recognizing receptors such as CD14, TLR4 and MD2, and they have intact TLR4 signaling.
Gene_expression (express) of MD2 in HSCs associated with cirrhosis and agonist
5) Confidence 0.14 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.64 Pain Relevance 0.87
In human embryonic kidney (HEK) 293-CD14-MD2 cell transfected with various TLR4 variants, Hodgkinson and Yee demonstrated that TLR4 variations and statins have an additive inhibitory effect on TLR4-mediated response to LPS, in term of NF?
Gene_expression (cell) of MD2 in MD2
6) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.19 Pain Relevance 0.04
On the other hand, TLR expression and MD2 expression were not affected by vitamin D3 in cultured human endothelial cells (HMEC) [87].
Gene_expression (expression) of MD2 in endothelial cells
7) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.30 Pain Relevance 0.05
LY379268 was effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
Gene_expression (effective) of LY379268 associated with epilepsy, pain, stroke, drug abuse and schizophrenia
8) Confidence 0.10 Published 2007 Journal CNS Drug Rev Section Abstract Doc Link 18078428 Disease Relevance 0.58 Pain Relevance 0.44
However, no significant differences in levels of mRNA expression for CD14 and MD-2, which are critically involved in LPS-mediated signal transduction of TLR, were found between patients and control individuals (data not shown).
Gene_expression (expression) of MD-2
9) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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