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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.83
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
macrophages 2
liver 2
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.42 Very High Very High Very High
Glutamate 2 99.32 Very High Very High Very High
ischemia 2 88.84 High High
Inflammation 45 80.52 Quite High
tolerance 43 74.32 Quite High
withdrawal 13 65.20 Quite High
Inflammatory response 4 57.72 Quite High
Bioavailability 1 38.56 Quite Low
Potency 7 23.12 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 99.98 Very High Very High Very High
Hepatitis C Virus Infection 2 99.76 Very High Very High Very High
Hepatitis 1 99.62 Very High Very High Very High
Pressure And Volume Under Development 1 96.84 Very High Very High Very High
Liver Disease 1 95.88 Very High Very High Very High
Stress 57 95.36 Very High Very High Very High
Lung Injury 1 92.64 High High
Organ Transplantation 1 90.64 High High
Reperfusion Injury 1 89.60 High High
Cv Unclassified Under Development 1 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.
Positive_regulation (increase) of Transcription (levels) of HO-1 associated with glutamate and paracetamol
1) Confidence 0.33 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.13 Pain Relevance 0.58
These data are consistent with earlier findings demonstrating increased Hmox1 transcription in RAW264.7 macrophages after luteolin treatment [60].
Positive_regulation (increased) of Transcription (transcription) of Hmox1 in macrophages
2) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.21 Pain Relevance 0.07
Even more, it was recently reported that hepatitis C (HCV) infection increased HO-1 mRNA expression and protein levels in human liver cells and was suggested to likely represent a protective response against possible oxidative or other insult from HCV proteins [36].
Positive_regulation (increased) of Transcription (expression) of HO-1 in liver associated with hepatitis c virus infection, infection and hepatitis
3) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 1.27 Pain Relevance 0.18
PETN concentration-dependently increased the HO-1 mRNA levels in EA.hy 926 cells resulting in a significant increase at 50 ?
Positive_regulation (increased) of Transcription (levels) of HO-1
4) Confidence 0.25 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.13 Pain Relevance 0.10
As expected, increased mRNA levels from three NRF2 target genes, HO-1, GSTa2, and GCLC were found in CRIF1 knockdown cells when compared with control cells (Fig. 7C).

Positive_regulation (increased) of Transcription (levels) of HO-1
5) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Complex I blockade upregulated the mRNA levels of glutamylcysteine synthetase heavy and light chains, glutathione-S-transferases omega1 and alpha 2, hemoxygenase 1, thioredoxin reductase 1, and selenoprotein H.
Positive_regulation (upregulated) of Transcription (levels) of hemoxygenase 1
6) Confidence 0.09 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1925139 Disease Relevance 0.10 Pain Relevance 0

General Comments

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