INT14849

Context Info Confidence 0.39 First Reported 1991 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 5.96 Pain Relevance 6.06

Anatomy Link Frequency saphenous nerve 2 neurons 1 autonomic 1 T lymphocytes 1 IgG-2a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 29 100.00 dorsal root ganglion 4 99.64 Morphine 12 99.48 Enkephalin 11 99.48 narcan 2 99.04 Multiple sclerosis 3 98.84 substance P 11 98.68 primary afferent fibers 2 98.08 antagonist 1 97.36 Pain 13 96.36

Disease Link Frequency Relevance Heat Necrosis 6 100.00 Cancer 6 100.00 Neuromyelitis Optica 9 99.98 Ganglion Cysts 4 99.64 Demyelinating Disease 4 98.84 Autonomic Dysreflexia 5 98.76 Nociception 3 97.12 Pain 11 96.36 Optic Neuritis 1 95.12 Frailty 6 93.92

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Binding studies carried out at 4 degrees C on MC and MP indicated that morphine did not modulate surface binding of IgG complexes.

IgG Binding (binding) of associated with morphine

1) Confidence 0.39 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8498540 Disease Relevance 0.07 Pain Relevance 1.08

Bound IgG1 or IgG2a/c was detected by incubation with horseradish peroxidase-conjugated sheep anti-mouse IgG1 (BD Biosciences), or an antibody that recognises both IgG2a and IgG2c (BD Biosciences), followed by TMB (3,3', 5,5'-tetramethylbenzidine) substrate.

IgG2a Binding (Bound) of

2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 0.49 Pain Relevance 0.19

Bound IgG1 or IgG2a/c was detected by incubation with horseradish peroxidase-conjugated sheep anti-mouse IgG1 (BD Biosciences), or an antibody that recognises both IgG2a and IgG2c (BD Biosciences), followed by TMB (3,3', 5,5'-tetramethylbenzidine) substrate.

IgG2a Binding (recognises) of

3) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 0.31 Pain Relevance 0.16

Primary antibodies included (1) anti-CD3 (monoclonal mouse IgG2a, Biocarta, Hamburg, Germany) to mark mucosal T lymphocytes, (2) anti-IgA antibody (?

IgG2a Binding (mark) of in T lymphocytes

4) Confidence 0.36 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1995200 Disease Relevance 0.45 Pain Relevance 0.14

The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves.

IgG Binding (bound) of in neurons associated with ganglion cysts and dorsal root ganglion

5) Confidence 0.05 Published 1995 Journal J. Neurol. Sci. Section Abstract Doc Link 8543935 Disease Relevance 0.90 Pain Relevance 0.27

The bispecific anti-SP antibody recognized HRP, whereas a secondary bispecific antibody recognized both the IgG of the anti-ENK monoclonal antibody and HRP.

IgG Binding (recognized) of associated with enkephalin and substance p

6) Confidence 0.04 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1707094 Disease Relevance 0.24 Pain Relevance 1.47

Here we applied a synthetic tyrosine kinase A IgG (trkA-IgG) fusion molecule for 10-12 days to the innervation territory of the purely cutaneous saphenous nerve in order to bind, and thereby neutralize endogenous NGF in adult rats.

IgG Binding (bind) of in saphenous nerve associated with nerve growth factor

7) Confidence 0.03 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749782 Disease Relevance 0.10 Pain Relevance 0.61

Here we applied a synthetic tyrosine kinase A IgG (trkA-IgG) fusion molecule for 10-12 days to the innervation territory of the purely cutaneous saphenous nerve in order to bind, and thereby neutralize endogenous NGF in adult rats.

IgG Binding (bind) of in saphenous nerve associated with nerve growth factor

8) Confidence 0.02 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749782 Disease Relevance 0.10 Pain Relevance 0.61

NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes NMO from MS.

IgG Binding (recognizes) of associated with neuromyelitis optica and multiple sclerosis

9) Confidence 0.02 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19545538 Disease Relevance 1.28 Pain Relevance 0.24

We also pretreated rats with a tumor necrosis factor receptor (TNFr) protein, p75 IgG fusion protein (5 to 10 mg/kg), to study the role of endogenous TNF in the development of pain behaviors after incision.

IgG Binding (rats) of associated with pain, necrosis and cancer

10) Confidence 0.01 Published 2004 Journal J Pain Section Abstract Doc Link 15106128 Disease Relevance 0.62 Pain Relevance 0.58

We hypothesized that binding of NGF in the injured cord by our trkA-IgG fusion protein would diminish autonomic dysreflexia.

IgG Binding (binding) of in autonomic associated with autonomic dysreflexia and nerve growth factor

11) Confidence 0.01 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12542855 Disease Relevance 1.18 Pain Relevance 0.59

Surface plasmon resonance experiments showed that 9O12.2 IgG bound to immobilized B–collagelin in a dose-dependent manner (Figure 1B) with a KD of 10?

IgG Binding (bound) of

12) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680759 Disease Relevance 0.25 Pain Relevance 0.12

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