INT148493

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mnat1) cell cycle (Mnat1) cytoplasm (Mnat1)
Anatomy Link Frequency
cortex 1
Mnat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 2 99.24 Very High Very High Very High
Nucleus accumbens 2 99.16 Very High Very High Very High
mu opioid receptor 2 97.52 Very High Very High Very High
tolerance 6 95.84 Very High Very High Very High
Analgesic 7 95.44 Very High Very High Very High
narcan 2 90.88 High High
Morphine 6 89.12 High High
withdrawal 2 88.40 High High
analgesia 2 86.04 High High
Physical dependence 4 84.32 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 99.24 Very High Very High Very High
Targeted Disruption 4 97.72 Very High Very High Very High
Drug Dependence 4 84.32 Quite High
Substance Withdrawal Syndrome 1 74.64 Quite High
Pain 1 68.76 Quite High
Congenital Anomalies 1 57.52 Quite High
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAT1 down-regulation had no effect, in agreement with findings that this protein is dispensable for basal expression of PGC-1 target genes [26].
Regulation (regulation) of MAT1
1) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0.25 Pain Relevance 0
Second, cdk5 and p35 protein levels were unchanged in caudate-putamen, nucleus accumbens and prefrontal cortex of mice displaying locomotor sensitization.
Neg (unchanged) Regulation (unchanged) of p35 protein in cortex associated with nucleus accumbens
2) Confidence 0.05 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18082850 Disease Relevance 0.55 Pain Relevance 1.86

General Comments

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