INT148495

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.42
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
brain 2
cortex 1
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
Central grey 4 99.60 Very High Very High Very High
Morphine 12 99.22 Very High Very High Very High
Nucleus accumbens 4 99.16 Very High Very High Very High
ischemia 48 98.92 Very High Very High Very High
mu opioid receptor 4 97.88 Very High Very High Very High
tolerance 12 96.20 Very High Very High Very High
Analgesic 14 95.80 Very High Very High Very High
amygdala 2 93.28 High High
Neuronal excitability 34 92.64 High High
Disease Link Frequency Relevance Heat
Transient Ischemic Attack 2 99.68 Very High Very High Very High
Urological Neuroanatomy 4 99.60 Very High Very High Very High
Sclerosis 4 99.24 Very High Very High Very High
Stroke 54 99.04 Very High Very High Very High
Convulsion 136 98.96 Very High Very High Very High
Malformations Of Cortical Development 4 97.44 Very High Very High Very High
Cv Unclassified Under Development 28 95.44 Very High Very High Very High
Targeted Disruption 154 92.84 High High
Status Epilepticus 14 90.80 High High
Epilepsy 32 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, cdk5 and p35 protein levels were unchanged in caudate-putamen, nucleus accumbens and prefrontal cortex of mice displaying locomotor sensitization.
Neg (unchanged) Regulation (unchanged) of cdk5 in cortex associated with nucleus accumbens
1) Confidence 0.58 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18082850 Disease Relevance 0.55 Pain Relevance 1.86
Therefore, the expression of behavioral adaptations to chronic morphine treatment was not associated with the regulation of micro opioid receptor, cdk5 or adenylate cyclase activity in relevant brain areas.
Regulation (regulation) of cdk5 in brain associated with opioid receptor and morphine
2) Confidence 0.58 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18082850 Disease Relevance 0.42 Pain Relevance 1.66
We also show that (S)-roscovitine regulates CDK5 in vivo activity after stroke, suggesting that CDK5 is involved in (S)-roscovitine in vivo beneficial effect on ischemic brain.


Regulation (regulates) of CDK5 in brain associated with stroke
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.92 Pain Relevance 0.15
Little is known about the regulation of Cdk5, but experiments show that there is a basal level of phosphorylation at Thr75 due to Cdk5 activity [108].
Regulation (regulation) of Cdk5
4) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
Interestingly, human hippocampal sclerosis is accompanied by p25 generation and altered Cdk5 activity [38].
Regulation (altered) of Cdk5 associated with sclerosis
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.44 Pain Relevance 0.09
Abnormal expression and dysregulation of Cdk5 and its cofactors have been demonstrated in tissues from human cortical dysplasia [53] and hippocampal sclerosis [38], [46], [54].
Regulation (dysregulation) of Cdk5 associated with malformations of cortical development and sclerosis
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.66 Pain Relevance 0.07
It has been shown that (R)-roscovitine reduced hyperphosporylation of the Tau protein, a major CDK5 target, after transient cerebral ischemia in rat, mainly by inhibiting CDK5 [21].
Regulation (target) of CDK5 associated with transient ischemic attack and ischemia
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.43 Pain Relevance 0.12

General Comments

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