INT148522

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0.25
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ2) transmembrane transport (KCNQ2)
Anatomy Link Frequency
oocytes 1
KCNQ2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 1 92.28 High High
addiction 8 70.48 Quite High
Action potential 96 65.96 Quite High
anticonvulsant 8 14.68 Low Low
sodium channel 72 11.12 Low Low
Spinal cord 32 5.00 Very Low Very Low Very Low
potassium channel 24 5.00 Very Low Very Low Very Low
unmyelinated 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Axonal channel 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 9 92.28 High High
Helminth Infection 32 81.92 Quite High
Adhesions 16 28.00 Quite Low
Targeted Disruption 16 13.04 Low Low
Epilepsy 24 5.00 Very Low Very Low Very Low
Myoclonus 8 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Isaacs Syndrome 8 5.00 Very Low Very Low Very Low
Ataxia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Screening of 20 CHO-K1 clones stably expressing KCNQ2/3 was performed on the IonWorks HT until the best clone (judged from seal rate, current level, and stability) was obtained.
Gene_expression (expressing) of KCNQ2
1) Confidence 0.75 Published 2007 Journal J Biomol Screen Section Abstract Doc Link 18087070 Disease Relevance 0.09 Pain Relevance 0.09
The KCNQ2/3 Anchor Is a Shared Feature of Extant Jawed Vertebrates
Gene_expression (/) of KCNQ2
2) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.04
KCNQ2 and KCNQ3 gene sequences encoding the anchors lie near the 3?
Gene_expression (sequences) of KCNQ2
3) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0
Third, signals for clustering KCNQ channels appeared considerably later than in NaV channels, after sequential gene duplications that first yielded KCNQ4 and KCNQ5, then the inferred common ancestor gene, KCNQ2/3.
Gene_expression (/) of KCNQ2
4) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03
The KCNQ2/3 Anchor Is a Shared Feature of Extant Jawed Vertebrates
Gene_expression (The) of KCNQ2
5) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.04
By mutation, the inferred common ancestor gene, KCNQ2/3, might have acquired a sequence weakly analogous to the NaV anchor at the 3?
Gene_expression (/) of KCNQ2
6) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0
Why do all mammalian NaV channels possess anchor motifs, but only KCNQ2 and KCNQ3 among the five KCNQ subunits?
Gene_expression (possess) of KCNQ2
7) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0.16 Pain Relevance 0
Although mammalian KCNQ3 is unable to traffic to the cell membrane when expressed alone in these oocytes, mammalian KCNQ2, KCNQ4 and KCNQ5 can co-assemble with KCNQ3 to form heteromeric channels that traffic to the surface and conduct very robustly [65].
Gene_expression (expressed) of KCNQ2 in oocytes
8) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.04
In shark–the next available model organism after lamprey and earliest of extant jawed vertebrates–KCNQ2 and KCNQ3 paralogues are both present.
Gene_expression (paralogues) of KCNQ2
9) Confidence 0.20 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03

General Comments

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