INT148531

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) signal transduction (TNFRSF11A)
extracellular region (Tnfsf11) plasma membrane (Tnfsf11) intracellular (Tnfsf11)
Anatomy Link Frequency
macrophage 1
osteoclasts 1
TNFRSF11A (Homo sapiens)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 98.24 Very High Very High Very High
Pain 3 89.52 High High
Osteoarthritis 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 60 100.00 Very High Very High Very High
Hypercalcemia 40 99.08 Very High Very High Very High
INFLAMMATION 3 98.24 Very High Very High Very High
Metastasis 1 93.16 High High
Necrosis 2 91.40 High High
Cancer 2 91.04 High High
Pain 1 89.52 High High
Spontaneous Fractures 1 88.92 High High
Malignant Neoplastic Disease 1 83.80 Quite High
Multiple Myeloma 1 82.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Denosumab (formerly called AMG 162) is a fully human IgG2 monoclonal antibody that binds with high affinity to human RANKL and blocks binding of RANKL to RANK [48].
RANK Binding (binding) of RANKL
1) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924518 Disease Relevance 0.19 Pain Relevance 0
By binding to its receptor RANK on osteoclastic precursors, RANKL controls the differentiation, proliferation, and survival of osteoclasts.
RANK Binding (binding) of RANKL in osteoclasts associated with osteoporosis
2) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924518 Disease Relevance 0.86 Pain Relevance 0.03
This article reviewed the factors implicated, such as receptor activator of nuclear factor-kappaB (RANK), receptor activator of nuclear factor-kappaB ligand (RANKL), osteoprotegerin (OPG), macrophage inflammatory protein-1alpha (MIP-1alpha), SDF-1 and Wnt pathway.
RANK Binding (ligand) of nuclear factor-kappaB in macrophage associated with inflammation
3) Confidence 0.03 Published 2007 Journal Zhongguo Shi Yan Xue Ye Xue Za Zhi Section Abstract Doc Link 18088497 Disease Relevance 0.72 Pain Relevance 0.14

General Comments

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