INT14854

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Context Info
Confidence 0.39
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.27
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
CD86 2
blood 2
monocytes 2
thymus 2
T-cells 2
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
Inflammation 56 99.48 Very High Very High Very High
intrathecal 1 97.80 Very High Very High Very High
Multiple sclerosis 102 95.60 Very High Very High Very High
cytokine 23 91.00 High High
metalloproteinase 1 89.28 High High
Neuritis 4 83.20 Quite High
headache 2 76.88 Quite High
anesthesia 3 74.08 Quite High
Disease Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
INFLAMMATION 54 99.48 Very High Very High Very High
Adhesions 3 99.30 Very High Very High Very High
Hookworm Infection 35 98.88 Very High Very High Very High
Cancer 38 98.72 Very High Very High Very High
Herpes Zoster 4 98.16 Very High Very High Very High
Demyelinating Disease 106 95.60 Very High Very High Very High
Necrosis 2 92.16 High High
Hyperoxia 6 91.96 High High
Adenocarcinoma 90 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is plausible that a lack of vitamin D in utero or early childhood can affect the expression of HLA-DRB1 in the thymus, and impacting on central deletion.
Regulation (affect) of Gene_expression (expression) of DRB1 in thymus
1) Confidence 0.39 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.32 Pain Relevance 0.08
There was no apparent effect on HLA-DR expression by CD20+ cells.
Neg (no) Regulation (effect) of Gene_expression (expression) of HLA-DR
2) Confidence 0.37 Published 1996 Journal Blood Section Abstract Doc Link 8555493 Disease Relevance 0.56 Pain Relevance 0.16
Effects on expression of HLA-DR by CD14+ cells were variable.
Regulation (Effects) of Gene_expression (expression) of HLA-DR
3) Confidence 0.37 Published 1996 Journal Blood Section Abstract Doc Link 8555493 Disease Relevance 0.58 Pain Relevance 0.17
To investigate any effect of vitamin D on the cell surface expression of HLA-DRB1, the HLA-DRB1*15 homozygous lymphoblastoid cell line PGF and the HLA-DRB1*07 homozygous lymphoblastoid DBB cell line were stained with anti-HLA-DRB1 antibody.
Spec (investigate) Regulation (effect) of Spec (investigate) Gene_expression (expression) of DRB1
4) Confidence 0.23 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0 Pain Relevance 0
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Regulation (changes) of Gene_expression (expression) of antigen-DR in T-cells associated with intrathecal
5) Confidence 0.19 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.63 Pain Relevance 0.61
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Regulation (regulated) of Gene_expression (expression) of HLA-DR in CD86 associated with hookworm infection
6) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.57 Pain Relevance 0
Expression of HLA-DR was affected to the same extent as the dying of monocytes in total PBMCs (Figure 4b).
Regulation (affected) of Gene_expression (Expression) of HLA-DR in monocytes
7) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.31 Pain Relevance 0.07
Effect of glycyrrhizin on pain and HLA-DR antigen expression on CD8-positive cells in peripheral blood of herpes zoster patients in comparison with other antiviral agents.
Regulation (Effect) of Gene_expression (expression) of HLA-DR in blood associated with pain, neuralgia and herpes zoster
8) Confidence 0.07 Published 1990 Journal Skin Pharmacol. Section Title Doc Link 1707284 Disease Relevance 0.55 Pain Relevance 0.60
Furthermore, the expression of HLA DR was only affected on MDCs prior (median 3162) to tumor removal compared to healthy controls (median 3046) (Figure 2C).
Regulation (affected) of Gene_expression (expression) of HLA DR associated with cancer
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.83 Pain Relevance 0
Pain intensity and HLA-DR antigen expression on CD8+ cells were assessed during and after treatment with GL.
Regulation (intensity) of Gene_expression (expression) of HLA-DR associated with pain
10) Confidence 0.05 Published 1990 Journal Skin Pharmacol. Section Abstract Doc Link 1707284 Disease Relevance 0.51 Pain Relevance 0.39
Finally, exposure to 95% O2 upregulated the expression of the adhesion molecule CD11b on AM, whereas the expression of HLA-DR and CD14 was not affected.
Neg (not) Regulation (affected) of Gene_expression (expression) of HLA-DR associated with adhesions
11) Confidence 0.03 Published 1997 Journal Eur. J. Med. Res. Section Abstract Doc Link 9110920 Disease Relevance 0.41 Pain Relevance 0.11

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