INT148542

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) extracellular region (ST3GAL4)
Golgi apparatus (ST3GAL4) plasma membrane (Trpv1) transmembrane transport (Trpv1)
Anatomy Link Frequency
neurons 2
ST3GAL4 (Homo sapiens)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 97.92 Very High Very High Very High
Pain 2 97.08 Very High Very High Very High
dorsal root ganglion 4 86.56 High High
Thermal hyperalgesia 1 75.00 Quite High
qutenza 1 68.44 Quite High
Hyperalgesia 1 55.76 Quite High
diabetic neuropathy 3 50.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 99.84 Very High Very High Very High
INFLAMMATION 1 97.92 Very High Very High Very High
Pain 1 97.08 Very High Very High Very High
Hyperalgesia 3 88.72 High High
Diabetes Mellitus 4 87.56 High High
Ganglion Cysts 4 86.56 High High
Peripheral Neuropathy 3 50.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results reveal that STZ has a direct action on neurons and modulates the expression and function of TRPV1, a nociceptive ion channel that is responsible for inflammatory thermal pain.
STZ Regulation (modulates) of Gene_expression (expression) of TRPV1 in neurons associated with nociception, pain and inflammation
1) Confidence 0.05 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18089839 Disease Relevance 0.97 Pain Relevance 0.51

General Comments

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