INT14857

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.16
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
striatum 3
radial 2
muscles 2
nucleus accumbens 1
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 18 100.00 Very High Very High Very High
Nucleus accumbens 4 99.76 Very High Very High Very High
Dopamine 18 96.08 Very High Very High Very High
Enkephalin 18 95.88 Very High Very High Very High
Pain 14 91.60 High High
antagonist 3 75.00 Quite High
adenocard 2 75.00 Quite High
spinal dorsal horn 1 63.92 Quite High
Neurotransmitter 2 63.44 Quite High
Neuropeptide 5 61.76 Quite High
Disease Link Frequency Relevance Heat
Pain 10 91.60 High High
Neck Pain 6 91.56 High High
Headache 2 79.96 Quite High
Urological Neuroanatomy 1 79.04 Quite High
Hyperalgesia 1 57.92 Quite High
Congenital Anomalies 1 57.60 Quite High
Hypersensitivity 3 50.00 Quite Low
Neuralgia 1 50.00 Quite Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that PPT levels were significantly decreased bilaterally over the masseter, temporalis, and upper trapezius muscles, and also the C5-C6 zygapophyseal joint (P < .001), but not over the tibialis anterior muscle (P = .4) in patients with mechanical chronic neck pain when compared to controls.
Negative_regulation (decreased) of Gene_expression (levels) of PPT in muscles associated with pain and neck pain
1) Confidence 0.42 Published 2010 Journal J Pain Section Abstract Doc Link 19945351 Disease Relevance 0.88 Pain Relevance 0.88
RESULTS: The analysis of variance showed that PPT levels were significantly bilaterally decreased over both trigeminal (supra-orbital, infra-orbital, and mental) and nontrigeminal (median, ulnar, and radial) nerves in children with FETTH as compared with control subjects (all sites, P < .001).
Negative_regulation (decreased) of Gene_expression (levels) of PPT in radial
2) Confidence 0.42 Published 2010 Journal Pediatrics Section Body Doc Link 20530075 Disease Relevance 0.08 Pain Relevance 0
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Negative_regulation (reduced) of Gene_expression (levels) of PPT mRNA in striatum associated with nucleus accumbens
3) Confidence 0.42 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28
On the other hand, KW-6002 did not alter the decreased gene expression of PPT in 6-OHDA-treated rats.
Negative_regulation (decreased) of Gene_expression (expression) of PPT
4) Confidence 0.37 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384245 Disease Relevance 0.08 Pain Relevance 0.27
Herbimycin A and genistein also decreased IL-1beta-induced expression of PPT mRNA-encoding transcripts and the levels of SP-li synthesized in the cells and secreted into the culture medium in a concentration-dependent manner.
Negative_regulation (decreased) of Gene_expression (expression) of PPT associated with substance p
5) Confidence 0.29 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.06 Pain Relevance 0.48
In contrast, a decreased developmental expression in SP and PPT mRNA was observed throughout the observation period.
Negative_regulation (decreased) of Gene_expression (expression) of PPT associated with substance p
6) Confidence 0.28 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1707436 Disease Relevance 0.06 Pain Relevance 1.11
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Negative_regulation (reduced) of in nucleus accumbens Gene_expression (levels) of PPT mRNA in striatum associated with nucleus accumbens
7) Confidence 0.14 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28

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