INT148576

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 8.96
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryonic kidney 1
rs (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 99.92 Very High Very High Very High
isoflurane 11 99.02 Very High Very High Very High
Crohn's disease 388 93.40 High High
antagonist 1 81.44 Quite High
Thalamus 2 75.00 Quite High
Inflammation 130 68.20 Quite High
analgesia 2 65.64 Quite High
Arthritis 39 5.00 Very Low Very Low Very Low
spinal inflammation 35 5.00 Very Low Very Low Very Low
rheumatoid arthritis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 511 98.40 Very High Very High Very High
Exfoliation Syndrome 122 97.68 Very High Very High Very High
Disease 547 93.40 High High
Targeted Disruption 3 86.32 High High
Glaucoma 591 81.28 Quite High
Familial Mediterranean Fever 8 75.00 Quite High
Colitis 32 74.40 Quite High
Cognitive Disorder 1 67.36 Quite High
Unconsciousness 3 65.12 Quite High
Sleep Disorders 2 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Gene_expression (expressed) of Rs in embryonic kidney associated with gaba and isoflurane
1) Confidence 0.37 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.34 Pain Relevance 0.95
The average serial correlation coefficients for WT SCN explants were negative (mean rs?
Gene_expression (mean) of rs
2) Confidence 0.26 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2953532 Disease Relevance 0 Pain Relevance 0
For the SNPs rs3825942 and rs2165241, three haplotypes were observed, with the haplotype G-C being at a significantly higher frequency in cases than in controls (p=0.002, OR=12.18, 95% CI: 1.61–92.09).
Gene_expression (observed) of rs2165241
3) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.27 Pain Relevance 0
For the SNPs rs3825942 and rs2165241, three haplotypes were observed, with the haplotype G-C being at a significantly higher frequency in cases than in controls (p=0.002, OR=12.18, 95% CI: 1.61–92.09).
Gene_expression (observed) of rs3825942
4) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.27 Pain Relevance 0
Sequencing and subsequent genotyping of variants located in this associated haplotype block identified three synonymous variants (D102D/rs224225, G138G/rs224224, A165A/rs224223) and one non-synonymous variant (R202Q/rs224222) located in MEFV exon 2 that were significantly associated with UC (rs224222: p?
Gene_expression (rs224224) of rs224224 associated with inflammatory bowel disease
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2745755 Disease Relevance 1.77 Pain Relevance 0.31
Sequencing and subsequent genotyping of variants located in this associated haplotype block identified three synonymous variants (D102D/rs224225, G138G/rs224224, A165A/rs224223) and one non-synonymous variant (R202Q/rs224222) located in MEFV exon 2 that were significantly associated with UC (rs224222: p?
Gene_expression (rs224224) of rs224225 associated with inflammatory bowel disease
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2745755 Disease Relevance 1.78 Pain Relevance 0.31
Sequencing and subsequent genotyping of variants located in this associated haplotype block identified three synonymous variants (D102D/rs224225, G138G/rs224224, A165A/rs224223) and one non-synonymous variant (R202Q/rs224222) located in MEFV exon 2 that were significantly associated with UC (rs224222: p?
Gene_expression (rs224222) of rs224222 associated with inflammatory bowel disease
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2745755 Disease Relevance 1.66 Pain Relevance 0.30
Additionally, the non-synonymous SNP R202Q/rs224222 was also significantly associated with UC (p?
Gene_expression (synonymous) of rs224222 associated with inflammatory bowel disease
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.60 Pain Relevance 0.09
There are six tag SNPs (rs948413, rs948414, rs10790289, rs3814762, rs883247, and rs883245), which can be found on HapMap.
Gene_expression (found) of rs3814762
9) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.14 Pain Relevance 0
There are six tag SNPs (rs948413, rs948414, rs10790289, rs3814762, rs883247, and rs883245), which can be found on HapMap.
Gene_expression (found) of rs10790289
10) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.19 Pain Relevance 0
There are six tag SNPs (rs948413, rs948414, rs10790289, rs3814762, rs883247, and rs883245), which can be found on HapMap.
Gene_expression (found) of rs948414
11) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.19 Pain Relevance 0
There are six tag SNPs (rs948413, rs948414, rs10790289, rs3814762, rs883247, and rs883245), which can be found on HapMap.
Gene_expression (found) of rs883247
12) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.14 Pain Relevance 0
There are six tag SNPs (rs948413, rs948414, rs10790289, rs3814762, rs883247, and rs883245), which can be found on HapMap.
Gene_expression (found) of rs883245
13) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.13 Pain Relevance 0
To replicate our results in an independent sample, we genotyped a set of eight SNPs consisting of the most strongly associated markers in the foregoing extension study (rs7849556, rs10817669, rs10759734, rs6478105, rs1982396, and rs10733612), the tag SNP (rs4979459) and one SNP located in the neighboring TNFSF15 gene (rs4246905) in an additional independent set of 232 cases and 149 controls (Figure 1, Table 3).
Gene_expression (set) of rs6478105
14) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
To replicate our results in an independent sample, we genotyped a set of eight SNPs consisting of the most strongly associated markers in the foregoing extension study (rs7849556, rs10817669, rs10759734, rs6478105, rs1982396, and rs10733612), the tag SNP (rs4979459) and one SNP located in the neighboring TNFSF15 gene (rs4246905) in an additional independent set of 232 cases and 149 controls (Figure 1, Table 3).
Gene_expression (set) of rs10817669
15) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
To replicate our results in an independent sample, we genotyped a set of eight SNPs consisting of the most strongly associated markers in the foregoing extension study (rs7849556, rs10817669, rs10759734, rs6478105, rs1982396, and rs10733612), the tag SNP (rs4979459) and one SNP located in the neighboring TNFSF15 gene (rs4246905) in an additional independent set of 232 cases and 149 controls (Figure 1, Table 3).
Gene_expression (set) of rs10759734
16) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
To replicate our results in an independent sample, we genotyped a set of eight SNPs consisting of the most strongly associated markers in the foregoing extension study (rs7849556, rs10817669, rs10759734, rs6478105, rs1982396, and rs10733612), the tag SNP (rs4979459) and one SNP located in the neighboring TNFSF15 gene (rs4246905) in an additional independent set of 232 cases and 149 controls (Figure 1, Table 3).
Gene_expression (set) of rs7849556
17) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
To replicate our results in an independent sample, we genotyped a set of eight SNPs consisting of the most strongly associated markers in the foregoing extension study (rs7849556, rs10817669, rs10759734, rs6478105, rs1982396, and rs10733612), the tag SNP (rs4979459) and one SNP located in the neighboring TNFSF15 gene (rs4246905) in an additional independent set of 232 cases and 149 controls (Figure 1, Table 3).
Gene_expression (set) of rs10733612
18) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.09 Pain Relevance 0.04
However, the SNPs genotyped in Chinese-Han are rs11217241, rs669462, rs848413, rs948414, rs12294677, rs10790289, rs12421909, rs2510143, rs3814762, rs4639950, rs883247, and rs883245 on HapMap.
Gene_expression (genotyped) of rs3814762
19) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.13 Pain Relevance 0
However, the SNPs genotyped in Chinese-Han are rs11217241, rs669462, rs848413, rs948414, rs12294677, rs10790289, rs12421909, rs2510143, rs3814762, rs4639950, rs883247, and rs883245 on HapMap.
Gene_expression (genotyped) of rs669462
20) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.13 Pain Relevance 0

General Comments

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