INT148577

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.44
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryonic kidney 1
rs (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 100.00 Very High Very High Very High
isoflurane 11 99.80 Very High Very High Very High
antagonist 1 83.00 Quite High
Thalamus 2 75.00 Quite High
analgesia 2 67.20 Quite High
Crohn's disease 60 5.00 Very Low Very Low Very Low
Inflammation 50 5.00 Very Low Very Low Very Low
spinal inflammation 35 5.00 Very Low Very Low Very Low
Arthritis 35 5.00 Very Low Very Low Very Low
psoriasis 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 87.88 High High
Unconsciousness 3 66.68 Quite High
Cognitive Disorder 1 66.56 Quite High
Sleep Disorders 2 63.84 Quite High
Amnesia 1 50.68 Quite High
Disease 90 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 35 5.00 Very Low Very Low Very Low
Low Back Pain 35 5.00 Very Low Very Low Very Low
INFLAMMATION 30 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Positive_regulation (activated) of Rs in embryonic kidney associated with gaba and isoflurane
1) Confidence 0.29 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.44 Pain Relevance 1.01
For SNPs that did not reach this threshold (rs4979459, rs10759734, rs6478105, rs10982396, and rs4246905) an alternative method of genotyping was used in order to resolve the correct genotype.
Neg (not) Positive_regulation (reach) of rs6478105
2) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0 Pain Relevance 0
For SNPs that did not reach this threshold (rs4979459, rs10759734, rs6478105, rs10982396, and rs4246905) an alternative method of genotyping was used in order to resolve the correct genotype.
Neg (not) Positive_regulation (reach) of rs4246905
3) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0 Pain Relevance 0
For SNPs that did not reach this threshold (rs4979459, rs10759734, rs6478105, rs10982396, and rs4246905) an alternative method of genotyping was used in order to resolve the correct genotype.
Neg (not) Positive_regulation (reach) of rs4979459
4) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0 Pain Relevance 0
For SNPs that did not reach this threshold (rs4979459, rs10759734, rs6478105, rs10982396, and rs4246905) an alternative method of genotyping was used in order to resolve the correct genotype.
Neg (not) Positive_regulation (reach) of rs10759734
5) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0 Pain Relevance 0
For SNPs that did not reach this threshold (rs4979459, rs10759734, rs6478105, rs10982396, and rs4246905) an alternative method of genotyping was used in order to resolve the correct genotype.
Neg (not) Positive_regulation (reach) of rs10982396
6) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0 Pain Relevance 0

General Comments

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