INT148578

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryonic kidney 2
rs (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 100.00 Very High Very High Very High
isoflurane 11 99.80 Very High Very High Very High
antagonist 1 83.00 Quite High
Thalamus 2 75.00 Quite High
analgesia 2 67.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 87.88 High High
Cognitive Disorder 1 67.36 Quite High
Unconsciousness 3 66.68 Quite High
Sleep Disorders 2 63.84 Quite High
Amnesia 1 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Positive_regulation (activated) of Gene_expression (expressed) of Rs in embryonic kidney associated with gaba and isoflurane
1) Confidence 0.29 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.45 Pain Relevance 1.01

General Comments

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