INT148579

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
thalamus 1
rs (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 9 100.00 Very High Very High Very High
isoflurane 11 99.84 Very High Very High Very High
Thalamus 2 99.00 Very High Very High Very High
antagonist 1 64.04 Quite High
analgesia 2 48.24 Quite Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 1 99.88 Very High Very High Very High
Glaucoma 84 98.84 Very High Very High Very High
Exfoliation Syndrome 122 98.68 Very High Very High Very High
Sleep Disorders 2 98.52 Very High Very High Very High
Obesity 4 77.76 Quite High
Targeted Disruption 3 68.92 Quite High
Disease 8 52.24 Quite High
Unconsciousness 3 47.72 Quite Low
Amnesia 1 31.72 Quite Low
Ocular Hypertension 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of the crucial role of the thalamus in sensory processing, sleep, and cognition, the modulation of these extrasynaptic GABA(A)-Rs by isoflurane may contribute to the sedation and hypnosis associated with low doses of this anesthetic agent.
Regulation (modulation) of Rs in thalamus associated with cognitive disorder, gaba, isoflurane, thalamus and sleep disorders
1) Confidence 0.15 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.27 Pain Relevance 0.72
Conditional haplotype-based association test showed that rs1048661 had independent haplotyic effect (p=3.6×10-7), and the association between the other two SNPs and the disorder was no longer significant after controlling for rs1048661 (p=0.0462), suggesting that this SNP is the major SNP contributing to the association.
Regulation (controlling) of rs1048661
2) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.74 Pain Relevance 0
However, when controlled for rs1048661, the association became insignificant, suggesting they are more likely to be genetic markers in LD with the rs1048661.
Regulation (controlled) of rs1048661
3) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.67 Pain Relevance 0

General Comments

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