INT1486

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 85
Total Number 86
Disease Relevance 28.78
Pain Relevance 54.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
striatum 8
fat 7
brain 4
pituitary 4
hypothalamus 3
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 529 100.00 Very High Very High Very High
narcan 79 100.00 Very High Very High Very High
Analgesic 45 100.00 Very High Very High Very High
Dynorphin 39 100.00 Very High Very High Very High
agonist 38 100.00 Very High Very High Very High
Dopamine 23 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
opioid receptor 120 99.84 Very High Very High Very High
noradrenaline 3 99.84 Very High Very High Very High
Morphine 457 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 17 100.00 Very High Very High Very High
Infection 64 99.92 Very High Very High Very High
Targeted Disruption 510 99.84 Very High Very High Very High
Parkinson's Disease 21 99.82 Very High Very High Very High
Convulsion 7 99.76 Very High Very High Very High
Cancer 162 99.60 Very High Very High Very High
Congenital Anomalies 6 99.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 99.44 Very High Very High Very High
Hypersensitivity 6 99.24 Very High Very High Very High
Alcohol Addiction 4 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carboxypeptidase E activity is deficient in mice with the fat mutation.
Negative_regulation (deficient) of Carboxypeptidase E in fat
1) Confidence 0.59 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.05
The results indicate significantly decreased leu-enkephalin content and significantly increased dynorphin/enkephalin content ratios in high-stereotypy mice relative to low-stereotypy mice.
Negative_regulation (decreased) of leu-enkephalin associated with dynorphin and enkephalin
2) Confidence 0.56 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15639187 Disease Relevance 0.06 Pain Relevance 0.87
The Met-enkephalin-Arg6-Phe7 level was found to be decreased only in the spinal cord and striatum of C57Bl10/D1 mice.
Negative_regulation (decreased) of Met-enkephalin-Arg6-Phe7 in striatum associated with enkephalin and spinal cord
3) Confidence 0.54 Published 1993 Journal Biull Eksp Biol Med Section Abstract Doc Link 7506073 Disease Relevance 0.09 Pain Relevance 0.49
A decrease in the Met-enkephalin levels and a decrease in the dopamine (DA) turnover in the striatum of these "conditioned suppression" groups have been exhibited.
Negative_regulation (decrease) of Met-enkephalin in striatum associated with dopamine and enkephalin
4) Confidence 0.48 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3422094 Disease Relevance 0.27 Pain Relevance 0.36
In addition, the combination of thiorphan and bestatin reversed the decreases of Met-enkephalin levels and the decreases of DA turnover in the striatum in conditioned suppression group.
Negative_regulation (decreases) of Met-enkephalin in striatum associated with dopamine and enkephalin
5) Confidence 0.48 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3422094 Disease Relevance 0.19 Pain Relevance 0.54
In the ethanol-treated group, there was a significant (P<0.05) reduction of the levels of Met-enkephalin in serum to 70.5% of control levels.
Negative_regulation (reduction) of Met-enkephalin associated with enkephalin
6) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.14 Pain Relevance 0.78
Met-enkephalin levels in whole brain homogenates often first paradoxically increase after a few days of ethanol drinking and then decrease with the development of physical dependence.
Negative_regulation (decrease) of Met-enkephalin in brain associated with physical dependence and enkephalin
7) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.17 Pain Relevance 0.80
There is an accumulation of C-terminally extended forms of all three opioid peptides in Cpe(fat)/Cpe(fat) mice, consistent with a lack of CPE activity.
Negative_regulation (lack) of CPE in fat associated with opioid
8) Confidence 0.43 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438557 Disease Relevance 0.26 Pain Relevance 0.60
Taken together, these results suggest that the lack of CPE activity leads to alterations in the level of opioid peptides during development and that changes in peptide levels differentially affect opioid receptor activity in vivo.
Negative_regulation (lack) of CPE associated with opioid receptor and opioid
9) Confidence 0.43 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438557 Disease Relevance 0.19 Pain Relevance 0.55
Mice with the fat mutation have previously been found to have a point mutation in the cpe gene, and to have greatly reduced levels of CPE-like enzyme activity in the pituitary and pancreatic islets (Naggert, J.
Negative_regulation (reduced) of CPE-like in pancreatic islets
10) Confidence 0.43 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.05
Previously, we developed a technique for the isolation of neuropeptide-processing intermediates from mice that lack carboxypeptidase E activity (Cpe fat/fat mice) due to a naturally occurring point mutation.
Negative_regulation (lack) of carboxypeptidase E in fat associated with neuropeptide
11) Confidence 0.43 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15572367 Disease Relevance 0 Pain Relevance 0.05
Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E.
Negative_regulation (lacking) of carboxypeptidase E in fat associated with opioid
12) Confidence 0.43 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12438557 Disease Relevance 0.23 Pain Relevance 0.55
Nalorphine (10(-5) M) reversed the inhibitory effect of met-enkephalin.
Negative_regulation (effect) of enkephalin associated with enkephalin
13) Confidence 0.42 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206750 Disease Relevance 0 Pain Relevance 0.84
The results indicate significantly decreased leu-enkephalin content and significantly increased dynorphin/enkephalin content ratios in high-stereotypy mice relative to low-stereotypy mice.
Negative_regulation (decreased) of leu-enkephalin associated with dynorphin and enkephalin
14) Confidence 0.41 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15639187 Disease Relevance 0.06 Pain Relevance 0.87
Naloxone decreased the Leu-enkephalin level in the control mice but did not affect it in the addicted mice.
Negative_regulation (decreased) of Leu-enkephalin associated with narcan and enkephalin
15) Confidence 0.40 Published 1981 Journal Peptides Section Abstract Doc Link 7196572 Disease Relevance 0.10 Pain Relevance 1.50
This hypothesis was investigated by using the systemically active mixed inhibitor of enkephalin degrading enzymes, RB 101.
Negative_regulation (inhibitor) of enkephalin associated with enkephalin
16) Confidence 0.39 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.08 Pain Relevance 0.88
Both naltrexone and the 60 Hz magnetic fields attenuated the enkephalin mediated reductions of spatial performance.
Negative_regulation (reductions) of enkephalin associated with enkephalin
17) Confidence 0.38 Published 1996 Journal J. Comp. Physiol. A Section Abstract Doc Link 8888582 Disease Relevance 0.09 Pain Relevance 0.53
During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin.
Negative_regulation (lacking) of enkephalin associated with analgesic, tolerance and enkephalin
18) Confidence 0.37 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11125007 Disease Relevance 0.34 Pain Relevance 0.70
Analysis of POMC and PE sorting in Neuro2a cells depleted of CPE by CPE antisense RNA, and Cpe(fat/fat) mouse pituitary cells lacking CPE showed missorting of both these molecules to the constitutive pathway in vivo.
Negative_regulation (depleted) of CPE in pituitary
19) Confidence 0.37 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12438160 Disease Relevance 0 Pain Relevance 0
Leu-enkephalin was found to impair and Met-enkephalin to enhance acquisition of a discriminated Y-maze shock-escape task in mice at equivalent doses (100 micrograms/kg, ip).
Negative_regulation (impair) of enkephalin associated with shock and enkephalin
20) Confidence 0.37 Published 1984 Journal Behav. Neurosci. Section Abstract Doc Link 6732926 Disease Relevance 0.25 Pain Relevance 0.72

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