INT14862

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 4 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Enkephalin 9 99.56 Very High Very High Very High
Nucleus accumbens 1 99.24 Very High Very High Very High
Dopamine 20 98.56 Very High Very High Very High
nMDA receptor 1 93.44 High High
agonist 1 85.20 High High
Neuropeptide 2 75.00 Quite High
monoamine 1 75.00 Quite High
Serotonin 1 46.32 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the absence of any effect of 5-HT(2) antagonist on the expression of PPT-A mRNA in intact animals is discussed.
Negative_regulation (absence) of Transcription (expression) of PPT associated with antagonist
1) Confidence 0.42 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.43
Similarly, PPT mRNA abundance was significantly decreased in dlCPu, dmCPu and aCPu but not in the accumbens.
Neg (not) Negative_regulation (decreased) of Transcription (abundance) of PPT mRNA
2) Confidence 0.35 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659290 Disease Relevance 0 Pain Relevance 0.13
A loss of more than 90% DA was necessary to result in increased levels of ME and its PPE mRNA and reduced levels of SP and its PPT mRNAs; however, increased levels of 5-HT could be observed at a lower degree of DA loss.
Negative_regulation (reduced) of Transcription (levels) of PPT associated with dopamine, enkephalin and substance p
3) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707718 Disease Relevance 0 Pain Relevance 1.24

General Comments

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