INT148637

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.92
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lifr)
Anatomy Link Frequency
spinal cord dorsal horn 1
dorsal root ganglion 1
Lifr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 34 86.48 High High
neurotrophin 3 1 70.32 Quite High
Nerve growth factor 1 68.80 Quite High
intrathecal 1 56.16 Quite High
Pain 13 50.00 Quite Low
dorsal root ganglion 10 50.00 Quite Low
Inflammatory response 6 32.92 Quite Low
Sciatica 6 10.00 Low Low
Spinal cord 17 5.40 Low Low
ischemia 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 24 85.36 High High
Injury 105 84.04 Quite High
Death 24 83.60 Quite High
Ganglion Cysts 11 83.36 Quite High
Pain 14 80.40 Quite High
Spinal Cord Injury 29 57.32 Quite High
INFLAMMATION 14 32.56 Quite Low
Frailty 2 24.16 Low Low
Infection 7 20.00 Low Low
Retroviridae Infections 2 15.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our analysis revealed no significant difference in the expression of Lifr, a receptor for LIF and a co-receptor for CNTF, or Cntfr, the primary receptor for CNTF.
Gene_expression (expression) of Lifr
1) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.23 Pain Relevance 0.10
Western blot was used to assess the expression of the NR1 subunit of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha, an inflammatory marker, within the affected L5 dorsal root ganglion and spinal cord dorsal horn.
Gene_expression (expression) of inhibitory factor kappabeta-alpha in spinal cord dorsal horn
2) Confidence 0.58 Published 2008 Journal Anesthesiology Section Body Doc Link 18156889 Disease Relevance 0.16 Pain Relevance 0
While there was no change in the expression of LIFR, the expression of gp130 and EGFR were elevated by 1.5- and 1.44-fold, respectively.
Gene_expression (expression) of LIFR
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.14 Pain Relevance 0
Gene array analysis validated by QRT-PCR revealed an increase in the expression of LIF and TGFß1 as well as their corresponding receptors, LIFR, gp130 and AK5 in the SVZ at 7 days recovery from H/I.
Gene_expression (expression) of LIFR
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.23 Pain Relevance 0.09
Western blot was used to assess the expression of the NR1 subunit of the N-methyl-D-aspartate receptor and inhibitory factor kappabeta-alpha, an inflammatory marker, within the affected L5 dorsal root ganglion and spinal cord dorsal horn.
Gene_expression (expression) of inhibitory factor kappabeta-alpha in dorsal root ganglion
5) Confidence 0.20 Published 2008 Journal Anesthesiology Section Body Doc Link 18156889 Disease Relevance 0.16 Pain Relevance 0

General Comments

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