INT148639

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 16.76
Pain Relevance 11.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
neurons 6
Leydig cells 2
serotonin neurons 2
brain 1
SLD 1
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 316 100.00 Very High Very High Very High
GABAergic 260 100.00 Very High Very High Very High
Glutamate 59 100.00 Very High Very High Very High
Serotonin 18 99.82 Very High Very High Very High
Dismenorea 7 99.28 Very High Very High Very High
endometriosis 6 98.82 Very High Very High Very High
Neurotransmitter 46 98.76 Very High Very High Very High
GABA receptor 34 98.44 Very High Very High Very High
primary afferent fibers 1 97.88 Very High Very High Very High
Central nervous system 52 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 197 100.00 Very High Very High Very High
Neuroma 158 100.00 Very High Very High Very High
Giant Axonal Neuropathy 7 99.72 Very High Very High Very High
Sleep Disorders 38 99.60 Very High Very High Very High
Epilepsy 10 99.60 Very High Very High Very High
Dysmenorrhea 7 99.28 Very High Very High Very High
Targeted Disruption 100 98.90 Very High Very High Very High
Nociception 8 98.88 Very High Very High Very High
Parkinson's Disease 2 98.84 Very High Very High Very High
Endometriosis (extended) 6 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine fibroids, and 47 endometriosis women with adenomyosis were stained immunohistochemically using the highly specific polyclonal rabbit antiprotein gene product 9.5 (PGP9.5) and monoclonal mouse antineurofilament protein.
Gene_expression (using) of antiprotein gene product 9.5 in uterine associated with pain, endometriosis, uterine fibroids and dismenorea
1) Confidence 0.59 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 19535047 Disease Relevance 1.47 Pain Relevance 1.02
INTERVENTION(S): Histologic sections of contiguous endometrial and myometrial tissues were stained immunohistochemically using the highly specific polyclonal rabbit antiprotein gene product 9.5 (PGP9.5) and monoclonal mouse antineurofilament protein (NF).
Gene_expression (using) of antiprotein gene product 9.5
2) Confidence 0.58 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19368910 Disease Relevance 0.17 Pain Relevance 0
Gamma-aminobutyric acid, which is synthesized by two isoforms of glutamate decarboxylase (GAD), inhibits the transfer of nociceptive signals from primary afferent fibers to the central nervous system.
Gene_expression (synthesized) of GAD in central nervous system associated with nociception, glutamate, generalized anxiety disorder, primary afferent fibers and central nervous system
3) Confidence 0.51 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19571163 Disease Relevance 0.72 Pain Relevance 0.50
Axons double labeled with TRPV1 and protein gene product (PGP) 9.5 were detected in the myenteric plexus, but PGP 9.5-immunoreactive cell bodies did not colocalize with TRPV1.
Gene_expression (bodies) of PGP 9.5-immunoreactive
4) Confidence 0.44 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19497956 Disease Relevance 0 Pain Relevance 0.48
Of these, UCH-L1 is neuron-specific and is expressed throughout the brain and in Lewy bodies, the pathological biomarker of Parkinson's disease.
Gene_expression (expressed) of UCH-L1 in brain associated with parkinson's disease and disease
5) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.57 Pain Relevance 0
Calpain small subunit 1 displayed increased expression in the neuromas, whilst guanine nucleotide-binding protein Go subunit alpha 2, ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1), gamma-synuclein, mimecan precursor were all down-regulated (Table 2).
Gene_expression (expression) of ubiquitin carboxyl-terminal hydrolase isozyme L1 associated with neuroma
6) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.57 Pain Relevance 0
Of the neurons that co-express GAD(67) mRNA and PPE mRNA, about 22% expressed 5-HT(3A) mRNA.
Gene_expression (express) of GAD in neurons associated with generalized anxiety disorder
7) Confidence 0.28 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18586398 Disease Relevance 0.46 Pain Relevance 0.66
Two isozymes of GAD, GAD65 and GAD67, are primarily expressed in GABAergic neurons [4,5].
Gene_expression (expressed) of GAD in GABAergic neurons associated with generalized anxiety disorder and gabaergic
8) Confidence 0.24 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.88 Pain Relevance 0.71
GABA is synthesized from glutamic acid by glutamate decarboxylase (GAD) [1] and is accumulated into synaptic vesicles by the vesicular GABA transporter (VGAT) [2,3].
Gene_expression (synthesized) of GAD in synaptic vesicles associated with glutamate, gaba and generalized anxiety disorder
9) Confidence 0.20 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.75 Pain Relevance 0.67
Indeed, most HA neurons contain the GABA-synthesizing enzyme GAD and GABA itself (see Haas and Panula, 2003 for review).
Gene_expression (synthesizing) of GAD in neurons associated with gaba and generalized anxiety disorder
10) Confidence 0.17 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.29 Pain Relevance 0.44
-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD, Vincent et al., 1983; Takeda et al., 1984) and GABA itself are found in most TM neurons (Ericson et al., 1991; Airaksinen et al., 1992), as is adenosine deaminase (ADA), the enzyme catalyzing adenosine into inosine (Senba et al., 1985; Staines et al., 1986).
Gene_expression (synthesizing) of GAD in neurons associated with adenocard, gaba and generalized anxiety disorder
11) Confidence 0.16 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.24 Pain Relevance 0.24
9 subunit results in increased gene expression of GABAergic receptor subunits and glutamic acid decarboxylase (GAD), the synthetic enzyme for GABA.
Gene_expression (expression) of GAD associated with gaba, generalized anxiety disorder and gabaergic
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.32 Pain Relevance 0.18
However, some serotonin neurons expressed the gamma-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD).
Gene_expression (expressed) of GAD in serotonin neurons associated with gaba, generalized anxiety disorder and serotonin
13) Confidence 0.13 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 20589909 Disease Relevance 0.18 Pain Relevance 1.09
However, some serotonin neurons expressed the gamma-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD).
Gene_expression (synthesizing) of GAD in serotonin neurons associated with gaba, generalized anxiety disorder and serotonin
14) Confidence 0.10 Published 2010 Journal J. Comp. Neurol. Section Abstract Doc Link 20589909 Disease Relevance 0.18 Pain Relevance 1.08
As neural crest cell-associated postnatal stem cells, SHED express a variety of neural cell markers including nestin, beta III tubulin, GAD, NeuN, GFAP, NFM, and CNPase [21].
Gene_expression (express) of GAD in stem cells associated with generalized anxiety disorder
15) Confidence 0.09 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.77 Pain Relevance 0
In this study, downregulation of the Gan1 gene and the gene protein product, gigaxonin, was validated via quantitative polymerase chain reaction ([qPCR] gene expression) and Western blot analyses (protein level).
Gene_expression (expression) of gene protein product associated with giant axonal neuropathy
16) Confidence 0.09 Published 2009 Journal Biol Res Nurs Section Abstract Doc Link 19398414 Disease Relevance 1.17 Pain Relevance 0.43
Finally, Lu et al. [4] showed that part of the SLD PS-on neurons could be GABAergic combining GAD and Fos staining after PS hypersomnia.
Gene_expression (staining) of GAD in SLD associated with generalized anxiety disorder, gabaergic and sleep disorders
17) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.55 Pain Relevance 0.53
There is a lower expression of GABA receptors in the fragile X knock out (KO) mouse (DÂ’Hulst et al. 2006) and an increased expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis in the KO mouse (El Idrissi et al. 2005).
Gene_expression (expression) of GAD associated with targeted disruption, gaba, generalized anxiety disorder and gaba receptor
18) Confidence 0.09 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.54 Pain Relevance 0.21
Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB receptors, it is possible that GABA may act as auto-/paracrine molecule to regulate Leydig cell function.
Gene_expression (biosynthetic) of GAD in Leydig cells associated with glutamate, gaba and generalized anxiety disorder
19) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC416489 Disease Relevance 0.10 Pain Relevance 0.48
Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB receptors, it is possible that GABA may act as auto-/paracrine molecule to regulate Leydig cell function.
Gene_expression (possess) of GAD in Leydig cells associated with glutamate, gaba and generalized anxiety disorder
20) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC416489 Disease Relevance 0.10 Pain Relevance 0.49

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