INT148648

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.54
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
neurons 2
DRG 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 100.00 Very High Very High Very High
dorsal root ganglion 8 99.84 Very High Very High Very High
antagonist 3 99.80 Very High Very High Very High
Eae 6 99.08 Very High Very High Very High
substance P 1 96.96 Very High Very High Very High
ischemia 2 96.56 Very High Very High Very High
Pain 6 95.12 Very High Very High Very High
Inflammation 1 75.76 Quite High
Neuropathic pain 2 75.00 Quite High
Angina 1 73.00 Quite High
Disease Link Frequency Relevance Heat
Colitis 6 100.00 Very High Very High Very High
Ganglion Cysts 14 99.84 Very High Very High Very High
Injury 7 99.08 Very High Very High Very High
Coronary Artery Disease 2 97.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 94.20 High High
Myocardial Infarction 1 92.76 High High
Nociception 6 86.48 High High
Pain 6 83.24 Quite High
INFLAMMATION 1 75.76 Quite High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither the VMR nor the P2X(3) mRNA level in DRG from OVX colitis rats was reversed by the complex of estrogen and progesterone.
Negative_regulation (reversed) of Transcription (level) of P2X in DRG associated with colitis
1) Confidence 0.29 Published 2009 Journal Steroids Section Abstract Doc Link 19628002 Disease Relevance 0.59 Pain Relevance 0.14
P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression.
Negative_regulation (reduced) of Transcription (expression) of P2X associated with antagonist and agonist
2) Confidence 0.23 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.10 Pain Relevance 0.75
SF decreased the increment of P2X(3) agonist-activated currents and P2X(3) mRNA expression in DRG neurons during CCI.
Negative_regulation (decreased) of Transcription (expression) of P2X in neurons associated with dorsal root ganglion, eae and agonist
3) Confidence 0.03 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18805451 Disease Relevance 1.67 Pain Relevance 1.06

General Comments

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