INT148649

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 8.11
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
DRG 3
choroid plexus 1
neurons 1
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 16 99.84 Very High Very High Very High
agonist 27 99.52 Very High Very High Very High
Eae 12 99.08 Very High Very High Very High
antagonist 9 98.94 Very High Very High Very High
ASIC 6 97.28 Very High Very High Very High
ischemia 6 96.90 Very High Very High Very High
substance P 3 95.24 Very High Very High Very High
Pain 21 95.12 Very High Very High Very High
Spinal cord 4 87.68 High High
Inflammation 5 84.04 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 34 99.84 Very High Very High Very High
Myocardial Infarction 3 99.84 Very High Very High Very High
Colitis 12 99.32 Very High Very High Very High
Injury 15 99.08 Very High Very High Very High
Coronary Artery Disease 6 97.44 Very High Very High Very High
Nociception 18 95.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 94.20 High High
Pain 19 93.84 High High
INFLAMMATION 5 84.04 Quite High
Cv General 3 Under Development 3 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The final model was of rat P2X2, based upon a manually constructed secondary structure alignment with the ASIC using the chick ?
Transcription (based) of P2X2 associated with asic
1) Confidence 0.43 Published 2010 Journal Trends in Biochemical Sciences Section Body Doc Link PMC2824114 Disease Relevance 0 Pain Relevance 0.09
However, neither the VMR nor the P2X(3) mRNA level in DRG from OVX colitis rats was reversed by the complex of estrogen and progesterone.
Transcription (level) of P2X in DRG associated with colitis
2) Confidence 0.35 Published 2009 Journal Steroids Section Abstract Doc Link 19628002 Disease Relevance 0.59 Pain Relevance 0.14
Estrogen altered visceromotor reflex and P2X(3) mRNA expression in a rat model of colitis.
Transcription (expression) of P2X associated with colitis
3) Confidence 0.31 Published 2009 Journal Steroids Section Title Doc Link 19628002 Disease Relevance 0.57 Pain Relevance 0.12
The results revealed that the myocardial ischemia induced the upregulation of P2X(3) receptor in function and morphous and P2X(3) receptor antagonist A-317491 inhibited P2X agonist activated currents and P2X(3) mRNA expression.
Transcription (expression) of P2X associated with coronary artery disease, antagonist, ischemia and agonist
4) Confidence 0.28 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 0.93 Pain Relevance 0.61
P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression.
Transcription (expression) of P2X associated with antagonist and agonist
5) Confidence 0.28 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.08 Pain Relevance 0.74
The I(ATP) amplitude and P2X(3) mRNA expression in myocardial ischemic injury group were much larger than those obtained in control group.
Transcription (expression) of P2X associated with myocardial infarction
6) Confidence 0.28 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.18 Pain Relevance 0.76
RT-PCR experiments have determined the expression of mRNA for P2X1, P2X2, P2X4, P2X5 P2X6 and P2X7 in choroid plexus [94,95] (Table 1).
Spec (determined) Transcription (expression) of P2X2 in choroid plexus
7) Confidence 0.22 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.04
Expression of the P2X(3) transcript in the DRG was unchanged 30 min and 1 h after formalin injection, but increased after 12 h.
Transcription (transcript) of P2X in DRG
8) Confidence 0.19 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.20 Pain Relevance 0.23
SF decreased the increment of P2X(3) agonist-activated currents and P2X(3) mRNA expression in DRG neurons during CCI.
Transcription (expression) of P2X in neurons associated with dorsal root ganglion, eae and agonist
9) Confidence 0.04 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18805451 Disease Relevance 1.63 Pain Relevance 1.03
The expression of P2X(3) mRNA in DRG neurons was analyzed by in situ hybridization.
Spec (analyzed) Transcription (expression) of P2X in DRG associated with dorsal root ganglion
10) Confidence 0.04 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18805451 Disease Relevance 1.61 Pain Relevance 1.03

General Comments

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