INT148658

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Csnk1a1) cell morphogenesis (Csnk1a1) chromosome (Csnk1a1)
cytoskeleton (Csnk1a1) nucleus (Csnk1a1) cell cycle (Csnk1a1)
Anatomy Link Frequency
neuronal 1
hippocampus 1
Csnk1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 8 100.00 Very High Very High Very High
Hippocampus 6 95.00 High High
ischemia 24 93.16 High High
Nav1.1 1 75.00 Quite High
nav1.3 1 75.00 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Transient Ischemic Attack 1 93.16 High High
Epilepsy 4 92.72 High High
Febrile Convulsions 1 89.96 High High
Generalized Epilepsy 1 89.08 High High
Stroke 27 88.16 High High
Convulsion 3 83.28 Quite High
Cv Unclassified Under Development 14 74.04 Quite High
Death 24 61.52 Quite High
Cancer 1 20.96 Low Low
Lung Cancer 1 12.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(S)-roscovitine indeed potently inhibits CDK1, CDK2, CDK7, CDK9 [37], as well as Erk1/Erk2 and CK1 [30], that play key roles in neuronal development and survival [38].
Negative_regulation (inhibits) of CK1 in neuronal
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.39 Pain Relevance 0.08
The present study was undertaken to detect sodium channel I alpha-isoform (Na(v)1.1), sodium channel III alpha-isoform (Na(v)1.3) and beta(1) subunit from both the level of mRNA and protein in SERs hippocampus compared with control Wistar rats.
Negative_regulation (detect) of I alpha-isoform in hippocampus associated with sodium channel and hippocampus
2) Confidence 0.07 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158113 Disease Relevance 0.59 Pain Relevance 0.66

General Comments

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