INT14867

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 30.05
Pain Relevance 11.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
puncture 3
B cells 3
CII 2
bands 2
T cell 2
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 7 100.00 Very High Very High Very High
intrathecal 177 99.98 Very High Very High Very High
Enkephalin 3 99.90 Very High Very High Very High
Arthritis 892 99.36 Very High Very High Very High
Neuritis 9 99.36 Very High Very High Very High
Migraine 18 98.56 Very High Very High Very High
Inflammation 361 98.04 Very High Very High Very High
antagonist 2 97.94 Very High Very High Very High
substance P 8 97.92 Very High Very High Very High
headache 28 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.84 Very High Very High Very High
Lumbar Puncture Related Headaches 34 99.58 Very High Very High Very High
Arthritis 941 99.36 Very High Very High Very High
Experimental Autoimmune Neuritis 7 99.36 Very High Very High Very High
Pancreatitis 6 99.16 Very High Very High Very High
Infection 80 99.12 Very High Very High Very High
Leptospirosis 86 99.06 Very High Very High Very High
Rheumatoid Arthritis 274 99.00 Very High Very High Very High
Lymphatic System Cancer 37 98.80 Very High Very High Very High
Disease 320 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (beta1-3)N-acetylgalactosamine produced the block.
Gene_expression (produced) of IgM
1) Confidence 0.67 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9879698 Disease Relevance 0 Pain Relevance 0
Infection with A. cantonensis produces a prominent intrathecal production of IgM, IgA and IgG seven to ten days after the beginning of symptoms as we have reported earlier [15].
Gene_expression (production) of IgM associated with infection and intrathecal
2) Confidence 0.54 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.65 Pain Relevance 0.22
In this study using the first diagnostic lumbar puncture, IgE intrathecal synthesis was demonstrated but not IgM, IgA or IgG synthesis.
Gene_expression (synthesis) of IgM in puncture associated with lumbar puncture related headaches and intrathecal
3) Confidence 0.54 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.67 Pain Relevance 0.22
The sensitivity (58%) and specificity (98.1%) of a rapid dipstick assay for the detection of S. typhi-specific immunoglobulin M were somewhat lower than those of culture but higher than those of the Widal test.
Gene_expression (detection) of immunoglobulin M
4) Confidence 0.50 Published 2002 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 12757221 Disease Relevance 0.96 Pain Relevance 0.09
Two monoclonal anti-idiotypic antibodies (anti-Id-135 and anti-Id-14, both of the IgM class) which interact with the binding site of opioid receptors were generated.
Gene_expression (generated) of IgM associated with opioid receptor
5) Confidence 0.44 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2833518 Disease Relevance 0 Pain Relevance 0.28
Consequently, intrathecal synthesis of this immunoglobulin can contribute to confirmation of the diagnosis, along with clinical symptoms, and can be an early marker of this neuroparasitosis.
Gene_expression (synthesis) of immunoglobulin associated with intrathecal
6) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.51 Pain Relevance 0.17
Intrathecal synthesis of immunoglobulin is detected when the point falls above the thick hyperbolic line marking the Q boundary (Q limit = 0%).
Gene_expression (synthesis) of immunoglobulin associated with intrathecal
7) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.21 Pain Relevance 0.08
The objective of this paper was to determine if the intrathecal synthesis of immunoglobulin E is produced during the acute phase of the disease.


Gene_expression (synthesis) of immunoglobulin associated with disease and intrathecal
8) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2607252 Disease Relevance 0.94 Pain Relevance 0.17
In an earlier study [9] on four patients diagnosed with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis, it was shown that a local IgE synthesis was detected in the first diagnostic lumbar puncture without intrathecal synthesis of immunoglobulin A (IgA), immunoglobulin M (IgM) or immunoglobulin G (IgG).
Gene_expression (synthesis) of immunoglobulin M in puncture associated with rhinitis, meningoencephalitis, lumbar puncture related headaches and intrathecal
9) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 1.18 Pain Relevance 0.21
The objective of this paper was to determine if the intrathecal synthesis of immunoglobulin E is produced during the acute phase of the disease.


Gene_expression (produced) of immunoglobulin associated with disease and intrathecal
10) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2607252 Disease Relevance 0.95 Pain Relevance 0.17
In an earlier study [9] on four patients diagnosed with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis, it was shown that a local IgE synthesis was detected in the first diagnostic lumbar puncture without intrathecal synthesis of immunoglobulin A (IgA), immunoglobulin M (IgM) or immunoglobulin G (IgG).
Gene_expression (synthesis) of IgM in puncture associated with rhinitis, meningoencephalitis, lumbar puncture related headaches and intrathecal
11) Confidence 0.42 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 1.18 Pain Relevance 0.21
20°C prior to analysis of anti-collagen type II specific IgM and IgG antibodies.
Gene_expression (specific) of IgM
12) Confidence 0.38 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 0.19 Pain Relevance 0.23
Briefly, the collagen was coated onto the 96-well plate and IgM was detected by goat anti-rat IgM conjugated with horse-reddish perxoidase (HRP) for 2 h at room temperature follower by staining with tetramethylbenzidine substrate.
Gene_expression (detected) of IgM
13) Confidence 0.38 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 0.08 Pain Relevance 0.21
P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased.
Gene_expression (levels) of IgM associated with pressure and volume under development and arthritis
14) Confidence 0.38 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2816374 Disease Relevance 1.35 Pain Relevance 0.41
Passive transfer with lymph node cells (LNC) or purified serum immunoglobulin from rats with EAN was employed to directly measure the contribution of B cells and anti-myelin antibodies to demyelination and disease.
Gene_expression (transfer) of immunoglobulin in B cells associated with demyelination, disease and neuritis
15) Confidence 0.37 Published 2001 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 11398840 Disease Relevance 1.18 Pain Relevance 0.72
B/T cell ratio was altered after phytol injection (Figure 3D), presumably through an increase of B cell number, because a tendency towards higher levels of IgG and IgM was also seen (Figure 3E).
Gene_expression (levels) of IgM in B cell
16) Confidence 0.35 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.28 Pain Relevance 0.05
The serum IgM and IgG levels against self-antigen collagen are important biomarkers in collagen-induced arthritis rat model.
Gene_expression (levels) of IgM associated with arthritis
17) Confidence 0.34 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 1.21 Pain Relevance 0.16
Additionally, the levels of IgG and IgM against self-antigen collagen and production of inflammatory cytokines, TNF-?
Gene_expression (levels) of IgM associated with inflammation and cytokine
18) Confidence 0.34 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 0.94 Pain Relevance 0.37
Previous research indicated that it could reduce immunoglobulin production by acting directly on B lymphocytes in both mice and humans, despite having no notable action on B-lymphocyte proliferation [1].
Gene_expression (production) of immunoglobulin in B-lymphocyte
19) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.73 Pain Relevance 0.35
To determine the effect of T-614 on immunoglobulin subclasses, the total serum levels of IgM, IgG1, IgG2a, and IgG2b subclasses were quantified.
Gene_expression (levels) of IgM
20) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.51 Pain Relevance 0.28

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