INT148671

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 24.32
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Aip) cytosol (Aip) nucleolus (Aip)
plasma membrane (Aip) nucleus (Aip) cytoplasm (Aip)
Anatomy Link Frequency
B-cell 2
Pancreas 1
pituitary 1
ducts 1
urine 1
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 41 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
imagery 96 99.82 Very High Very High Very High
amygdala 8 97.04 Very High Very High Very High
metalloproteinase 5 95.84 Very High Very High Very High
Inflammation 25 95.08 Very High Very High Very High
fibrosis 44 94.24 High High
diclofenac 1 94.24 High High
peripheral neuropathy 1 93.60 High High
abdominal pain 30 91.12 High High
Disease Link Frequency Relevance Heat
Pancreatitis 508 100.00 Very High Very High Very High
Porphyria 6 100.00 Very High Very High Very High
Acute Intermittent Porphyria 5 100.00 Very High Very High Very High
Recurrence 21 99.76 Very High Very High Very High
Cancer 260 99.70 Very High Very High Very High
Hodgkin's Disease 64 99.68 Very High Very High Very High
Congenital Anomalies 10 99.60 Very High Very High Very High
Pancreatic Cancer 8 99.42 Very High Very High Very High
Adrenal Cancer 80 98.88 Very High Very High Very High
Hyponatremia 4 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we observed decreased AIP mRNA and protein expression in the adrenocortical tissue when compared to normal controls (Figure 3C and 3D).
Gene_expression (expression) of AIP
1) Confidence 0.63 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.82 Pain Relevance 0
In contrast, normal AIP protein expression and no LOH for 11q13.3 locus were verified in the B-cell non-Hodgkin lymphoma from the same patient (Figure 4).
Gene_expression (expression) of AIP in B-cell associated with hodgkin's disease
2) Confidence 0.63 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.71 Pain Relevance 0
Before therapy for AIP is begun, accurate diagnosis of AIP is necessary.
Gene_expression (diagnosis) of AIP associated with pancreatitis
3) Confidence 0.58 Published 2008 Journal Adv Med Sci Section Abstract Doc Link 18762470 Disease Relevance 1.36 Pain Relevance 0.13
Before the diagnosis of AIP was made, the patient was treated with drugs which are not considered to be safe in porphyric patients, such as phenytoin, metoclopramide, and diclofenac.
Gene_expression (diagnosis) of AIP associated with porphyria and diclofenac
4) Confidence 0.58 Published 2008 Journal Singapore Med J Section Abstract Doc Link 18946596 Disease Relevance 1.19 Pain Relevance 0.52
CONCLUSIONS: Focal-type AIP is not a rare clinical entity and might be buried in previously resected pancreatic specimens that in the past were diagnosed simply as mass-forming pancreatitis.


Gene_expression (buried) of AIP
5) Confidence 0.56 Published 2008 Journal Scand. J. Gastroenterol. Section Body Doc Link 18158696 Disease Relevance 0.26 Pain Relevance 0
AIP gene expression in normal adrenals and the adrenocortical tumor of the IFS AIP-mutated patient
Gene_expression (expression) of AIP gene associated with cancer
6) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.00 Pain Relevance 0
Low AIP gene expression was confirmed by qPCR in the adrenocortical carcinoma.
Gene_expression (expression) of AIP gene associated with adrenal cancer
7) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2862671 Disease Relevance 1.01 Pain Relevance 0
Both tumors displayed low AIP protein expression levels.
Gene_expression (expression) of AIP associated with cancer
8) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2862671 Disease Relevance 1.01 Pain Relevance 0
METHODS: We evaluated 178 patients presenting to our Pancreas Clinic between January 2005 and June 2006 for evaluation of the etiology of their suspected pancreatitis; AIP was diagnosed when patients met HISORt (Histology, Imaging features, Serology, Other organ involvement and Response to steroid treatment) criteria.
Gene_expression (diagnosed) of AIP in Pancreas
9) Confidence 0.47 Published 2010 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 19800984 Disease Relevance 0.09 Pain Relevance 0
The fact that AIP interacts with phosphodiesterases type 4A (PDE4A) and type 2A (PDE2A) implicates this gene in the cyclic AMP (cAMP) signaling cascade,12,13 a cellular pathway known to be disrupted in pituitary, but also in thyroid and adrenal tumorigenesis.14,15 Furthermore, AIP is widely expressed, which may argue in favor of a potential involvement of this gene also in non-pituitary tumors.
Gene_expression (expressed) of AIP in pituitary associated with pituitary cancer
10) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.27 Pain Relevance 0
Normal AIP protein expression was observed in the index patientÂ’s B-cell lymphoma when compared to the amygdala lymphoid tissue, which was used as a control (Figure 4).



Gene_expression (expression) of AIP in B-cell associated with lymphatic system cancer and amygdala
11) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.78 Pain Relevance 0.05
AIP expression was assessed through quantitative PCR (qPCR) and immunohistochemistry.


Gene_expression (expression) of AIP
12) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2862671 Disease Relevance 0.70 Pain Relevance 0
SUMMARY: Researchers this last year have further characterized clinical aspects of chronic pancreatitis that may lead to improved detection of early chronic pancreatitis and AIP, risk stratification and application of risk-lowering strategies to prevent relapses in AIP or the development of recurrent (and possibly chronic) alcoholic pancreatitis and new evidence that antioxidants may have a modest effect on reducing the dominant symptom in chronic pancreatitis, abdominal pain.


Gene_expression (lead) of AIP
13) Confidence 0.32 Published 2009 Journal Curr. Opin. Gastroenterol. Section Body Doc Link 19535979 Disease Relevance 0 Pain Relevance 0
Two days after admission, the patient developed seizures as a result of hyponatremia due to SIADH, which, together with the observation of red urine, led to the diagnosis of AIP.
Gene_expression (diagnosis) of AIP in urine associated with hyponatremia, convulsion and acute intermittent porphyria
14) Confidence 0.32 Published 2010 Journal Gastroenterol Hepatol Section Abstract Doc Link 20435380 Disease Relevance 1.63 Pain Relevance 0.22
SUMMARY: Researchers this last year have further characterized clinical aspects of chronic pancreatitis that may lead to improved detection of early chronic pancreatitis and AIP, risk stratification and application of risk-lowering strategies to prevent relapses in AIP or the development of recurrent (and possibly chronic) alcoholic pancreatitis and new evidence that antioxidants may have a modest effect on reducing the dominant symptom in chronic pancreatitis, abdominal pain.


Gene_expression (detection) of AIP
15) Confidence 0.32 Published 2009 Journal Curr. Opin. Gastroenterol. Section Body Doc Link 19535979 Disease Relevance 0 Pain Relevance 0
We studied 39 pancreatic resections with AIP, defined by the following triad of features: (1) lymphoplasmacytic infiltrates around ducts, (2) acinar lymphoplasmacytic inflammation with atrophy and fibrosis, and (3) obliterative phlebitis.
Gene_expression (resections) of AIP in ducts associated with fibrosis, inflammation, cv general 2 under development, frailty and pancreatitis
16) Confidence 0.23 Published 2008 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18779731 Disease Relevance 1.50 Pain Relevance 0.17
Recurrences were observed in 25% of cases, and were more frequent in focal AIP (33%) than in diffuse AIP (12%) (P=0.043), in smokers than in non-smokers (41% vs. 15%; P=0.011), and in patients with pathological serum levels of IgG4 compared to those with normal serum levels (50% vs. 12%; P=0.009).
Gene_expression (frequent) of AIP
17) Confidence 0.21 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19568232 Disease Relevance 0.07 Pain Relevance 0
Recurrences were observed in 25% of cases, and were more frequent in focal AIP (33%) than in diffuse AIP (12%) (P=0.043), in smokers than in non-smokers (41% vs. 15%; P=0.011), and in patients with pathological serum levels of IgG4 compared to those with normal serum levels (50% vs. 12%; P=0.009).
Gene_expression (frequent) of AIP
18) Confidence 0.21 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19568232 Disease Relevance 0.07 Pain Relevance 0
The prognosis of AIP appears to be good over the short-term with steroid therapy.
Gene_expression (prognosis) of AIP associated with pancreatitis
19) Confidence 0.17 Published 2010 Journal J. Gastroenterol. Section Abstract Doc Link 20213336 Disease Relevance 1.06 Pain Relevance 0.16
AIP sometimes mimics pancreatic cancer in its presentation, but as AIP responds dramatically to steroid therapy, accurate diagnosis is necessary.
Gene_expression (responds) of AIP associated with pancreatic cancer and pancreatitis
20) Confidence 0.15 Published 2010 Journal Nat Rev Gastroenterol Hepatol Section Abstract Doc Link 20548323 Disease Relevance 1.15 Pain Relevance 0.07

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