INT148686

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.27
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C6) extracellular region (C6) molecular_function (C6)
Anatomy Link Frequency
spine 1
vesicles 1
median nerves 1
C6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 8 99.72 Very High Very High Very High
Neuropeptide 2 91.60 High High
metalloproteinase 2 82.60 Quite High
Inflammation 18 79.28 Quite High
Central nervous system 58 77.76 Quite High
Pain 6 67.88 Quite High
cytokine 8 65.40 Quite High
Spinal cord 115 62.08 Quite High
Sciatica 1 46.16 Quite Low
dorsal rhizotomy 1 36.48 Quite Low
Disease Link Frequency Relevance Heat
Hyperplasia 100 99.84 Very High Very High Very High
Ganglion Cysts 8 99.72 Very High Very High Very High
Disease 70 99.26 Very High Very High Very High
Cardiovascular Disease 43 97.04 Very High Very High Very High
Osteoarthritis 53 91.12 High High
Increased Venous Pressure Under Development 15 88.92 High High
Drug Induced Neurotoxicity 6 88.36 High High
Injury 118 87.68 High High
Osteophyte 4 86.24 High High
Necrosis 2 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, several studies have suggested that exposure of cultured PMNs to biological or pharmacological stimulation induces the release of several critical terminal proteins (C6 and C7) in PMN cultures [18,19]; however, the expression of mRNAs encoding for C6 or C7 by PMNs has not been confirmed.
Localization (release) of C6
1) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 1.19 Pain Relevance 0.22
The lack of terminal complement mRNAs in cultured PMNs may not have been unexpected because several studies have suggested that C6 and C7 are not actively synthesized by PMNs in culture, but were likely presynthesized in PMNs during differentiation in the bone marrow, stored in cytoplasmic vesicles, and subsequently released during circulation [18,34].
Localization (released) of C6 in vesicles
2) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.06 Pain Relevance 0.06
Consequently, a remarkable increase in disease duration with disease severity was observed in our study, ranging from 20.1 years for C2, via 23.4 years and 25.3 years for C3 and C4, respectively, to 29.8 years for C5&C6.
Localization (ranging) of C6 associated with disease
3) Confidence 0.25 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 1.31 Pain Relevance 0
With fluorogold (FG) injection into normal median nerves, numerous FG-labeled DRG neurons were localized predominantly in the C6 and C7 DRGs, where the focal regions were examined after CMNT.
Localization (localized) of C6 in median nerves associated with dorsal root ganglion
4) Confidence 0.10 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 18159999 Disease Relevance 0.41 Pain Relevance 0.29
CPH was judged to be generally present/absent within the cervical spine as a whole, regardless of whether hyperplastic pillars were detected at one or more levels from C3 to C6), the etiology and clinical relevance of CPH remain unknown.
Localization (relevance) of C6 in spine associated with hyperplasia
5) Confidence 0.05 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 1.30 Pain Relevance 0.07

General Comments

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