INT1487

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Context Info
Confidence 0.62
First Reported 1978
Last Reported 2010
Negated 9
Speculated 5
Reported most in Title
Documents 68
Total Number 73
Disease Relevance 10.24
Pain Relevance 52.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 7
striatum 2
blood 2
cerebral cortex 2
mossy fiber 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 482 100.00 Very High Very High Very High
Opioid 68 100.00 Very High Very High Very High
narcan 56 100.00 Very High Very High Very High
Dynorphin 43 100.00 Very High Very High Very High
Neuropeptide 33 100.00 Very High Very High Very High
Eae 21 100.00 Very High Very High Very High
Analgesic 20 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
tolerance 17 100.00 Very High Very High Very High
Cholecystokinin 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Burns 2 99.98 Very High Very High Very High
Stress 17 99.82 Very High Very High Very High
Sprains And Strains 14 99.76 Very High Very High Very High
Neuropathic Pain 9 99.24 Very High Very High Very High
Shock 6 99.20 Very High Very High Very High
Convulsion 16 99.18 Very High Very High Very High
Nociception 62 99.16 Very High Very High Very High
Targeted Disruption 216 99.06 Very High Very High Very High
Ganglion Cysts 4 99.00 Very High Very High Very High
Depression 4 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 6 to 8 weeks, an age prior to the onset of obesity, levels of dynorphin peptides are decreased in all brain regions, whereas levels of ir-Met-enkephalin are differentially altered.
Regulation (altered) of ir-Met-enkephalin in brain associated with dynorphin, obesity and enkephalin
1) Confidence 0.62 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438557 Disease Relevance 0.26 Pain Relevance 0.59
Excitatory amino acid regulation of the enkephalin phenotype in mouse embryonic spinal cord cultures.
Regulation (regulation) of enkephalin in spinal cord associated with enkephalin, spinal cord and excitatory amino acid
2) Confidence 0.47 Published 1993 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 8353931 Disease Relevance 0 Pain Relevance 0.83
In contrast, ethanol treatment did not affect Met-enkephalin levels in the striatal tissue.
Neg (not) Regulation (affect) of Met-enkephalin associated with enkephalin
3) Confidence 0.46 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.15 Pain Relevance 0.81
Effect of enkephalin and substance P on sympathetic nerve transmission in mouse vas deferens.
Regulation (Effect) of enkephalin in vas deferens associated with enkephalin and substance p
4) Confidence 0.44 Published 1978 Journal Jpn. J. Pharmacol. Section Title Doc Link 206750 Disease Relevance 0 Pain Relevance 0.98
Effect of methionine-, leucine-enkephalin (met-, leu-enkephalin) and substance P on the transmission in mouse vas deferens was studied.
Regulation (Effect) of leucine-enkephalin in vas deferens associated with enkephalin and substance p
5) Confidence 0.44 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206750 Disease Relevance 0 Pain Relevance 0.80
There was no effect of leucine-enkephalin when administered just prior to testing on Day 5.
Neg (no) Regulation (effect) of leucine-enkephalin associated with enkephalin
6) Confidence 0.44 Published 1986 Journal Behav. Neurosci. Section Abstract Doc Link 3964420 Disease Relevance 0 Pain Relevance 0.67
Long-term effects of leucine-enkephalin on active avoidance responding in mice.
Regulation (effects) of leucine-enkephalin associated with enkephalin
7) Confidence 0.44 Published 1986 Journal Behav. Neurosci. Section Title Doc Link 3964420 Disease Relevance 0 Pain Relevance 0.62
Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations.
Regulation (changes) of Leu-enkephalin in brain associated with stress, dynorphin and enkephalin
8) Confidence 0.44 Published 1992 Journal Life Sci. Section Title Doc Link 1352028 Disease Relevance 0.19 Pain Relevance 1.23
The effect of enkephalin dimers on body temperature in mice.
Regulation (effect) of enkephalin in body associated with enkephalin
9) Confidence 0.42 Published 1987 Journal Peptides Section Title Doc Link 3658811 Disease Relevance 0.09 Pain Relevance 0.60
Effect of Leu-enkephalin on the memory reactivation produced by blockade of the benzodiazepine/GABA-chloride ionophore receptor complex.
Regulation (Effect) of Leu-enkephalin associated with gaba and enkephalin
10) Confidence 0.40 Published 1995 Journal Brain Res. Section Title Doc Link 7743204 Disease Relevance 0 Pain Relevance 0.55
Opposite effects of Met-enkephalin and Leu-enkephalin on a discriminated shock-escape task.
Regulation (effects) of enkephalin associated with shock, narcan and enkephalin
11) Confidence 0.39 Published 1984 Journal Behav. Neurosci. Section Title Doc Link 6732926 Disease Relevance 0.28 Pain Relevance 0.87
Opposite effects of Met-enkephalin and Leu-enkephalin on a discriminated shock-escape task.
Regulation (effects) of enkephalin associated with shock, narcan and enkephalin
12) Confidence 0.39 Published 1984 Journal Behav. Neurosci. Section Title Doc Link 6732926 Disease Relevance 0.28 Pain Relevance 0.86
Role of hippocampal Met-enkephalin in the genotype-dependent regulation of exploratory behavior in mice.
Regulation (Role) of Met-enkephalin associated with enkephalin
13) Confidence 0.39 Published 1986 Journal J. Neurogenet. Section Title Doc Link 3734950 Disease Relevance 0.18 Pain Relevance 0.32
Prolonged morphine administration changes neither met-enkephalin levels, nor the density of the opiate receptors in mice brain.
Neg (nor) Regulation (changes) of met-enkephalin in brain associated with opiate, enkephalin and morphine
14) Confidence 0.39 Published 1984 Journal Life Sci. Section Abstract Doc Link 6328141 Disease Relevance 0 Pain Relevance 1.65
Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations.
Regulation (changes) of Met-enkephalin in brain associated with stress, dynorphin and enkephalin
15) Confidence 0.38 Published 1992 Journal Life Sci. Section Title Doc Link 1352028 Disease Relevance 0.19 Pain Relevance 1.22
We compared these concentrations with the levels of preproenkephalin (PPE) mRNA and with the activity of peptide transport system-1 (PTS-1), a brain-to-blood transport system for Met-enkephalin that is affected by ethanol.
Regulation (affected) of Met-enkephalin in blood associated with enkephalin
16) Confidence 0.38 Published 1998 Journal Alcohol Section Abstract Doc Link 9426834 Disease Relevance 0.49 Pain Relevance 0.91
In the present study, the effects of leu-enkephalin and spinorphin on allodynia and mechanical and thermal nociceptions were examined in vivo using mice.
Regulation (effects) of leu-enkephalin associated with allodynia and enkephalin
17) Confidence 0.36 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11829145 Disease Relevance 0.47 Pain Relevance 1.36
Our results indicate that the activity-dependent establishment of the enkephalin phenotype is modulated through the selective activation of the NMDA-glutamate receptor.
Regulation (modulated) of enkephalin associated with glutamate receptor and enkephalin
18) Confidence 0.35 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8353931 Disease Relevance 0 Pain Relevance 0.70
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Regulation (control) of Met-enkephalin associated with enkephalin and alcohol
19) Confidence 0.34 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.13 Pain Relevance 0.66
The level of Met-enkephalin in the brain is inversely correlated with ethanol consumption and is controlled partially through efflux activity of peptide transport system-1 (PTS-1) at the blood-brain barrier (BBB).
Regulation (controlled) of Met-enkephalin in brain associated with enkephalin
20) Confidence 0.34 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.06 Pain Relevance 0.48

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