INT14870

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Context Info
Confidence 0.46
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.12
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TGFA) extracellular space (TGFA) extracellular region (TGFA)
plasma membrane (TGFA) nucleus (TGFA)
Anatomy Link Frequency
fibroblast 2
TGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 85.36 High High
Pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 67 99.04 Very High Very High Very High
Recurrence 6 98.72 Very High Very High Very High
Pancreatic Cancer 4 98.12 Very High Very High Very High
Chordoma 131 97.72 Very High Very High Very High
Aggression 2 93.44 High High
Pancreatitis 3 85.36 High High
Malignant Neoplastic Disease 6 81.68 Quite High
Chondrosarcoma 4 73.96 Quite High
Adhesions 2 66.88 Quite High
Aneuploidy 1 53.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is in vitro evidence that simultaneous overproduction of one of its ligands, transforming growth factor alpha (TGF-alpha), might result in an autocrine loop with an increased proliferation signal.
Positive_regulation (overproduction) of Gene_expression (overproduction) of transforming growth factor alpha
1) Confidence 0.46 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.53 Pain Relevance 0.15
High levels of transforming growth factor alpha and basic fibroblast growth factor expression were linked to higher rates of recurrence and strong fibronectin expression was also associated with poor prognosis, being thus considered an additional marker of aggressiveness [92].


Positive_regulation (levels) of Gene_expression (expression) of transforming growth factor alpha in fibroblast associated with aggression and recurrence
2) Confidence 0.04 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.59 Pain Relevance 0

General Comments

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