INT148702

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Context Info
Confidence 0.31
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 12.90
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
plasma 1
Blood 1
erythrocyte 1
germline 1
amygdala 1
UPF1 (Homo sapiens)
UPF1 - R122H (2) UPF1 - G20210A (1)
Pain Link Frequency Relevance Heat
drug abuse 521 99.36 Very High Very High Very High
amygdala 9 99.24 Very High Very High Very High
cva 1 99.08 Very High Very High Very High
cannabis 144 93.68 High High
cocaine 254 92.92 High High
Inflammation 83 92.68 High High
agonist 3 92.40 High High
abdominal pain 3 91.88 High High
headache 5 90.60 High High
Chronic pancreatitis 8 88.44 High High
Disease Link Frequency Relevance Heat
Disease 365 99.98 Very High Very High Very High
Thrombophilia 1 99.84 Very High Very High Very High
Dengue Hemorrhagic Fever 205 99.68 Very High Very High Very High
Drug Dependence 531 99.36 Very High Very High Very High
Thrombosis Related Under Development 2 99.08 Very High Very High Very High
Familial Dysautonomia 121 99.00 Very High Very High Very High
Disorder Of Lipid Metabolism 49 98.56 Very High Very High Very High
Suicidal Behaviour 24 98.16 Very High Very High Very High
Obesity 135 98.08 Very High Very High Very High
Syndrome 299 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discussion about coping with the housing situation in Accra centred around the difficulties in accumulating and paying advance rent.
Positive_regulation (accumulating) of advance rent
1) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
I was able to raise sufficient advance rent by working very hard … I work all day at the store … so also is my husband, we had no choice but to do that in order to raise enough money for our advance rent…now we are focused on saving some money as we have only a year left before the landlord will start asking for a new rent contract…(F, 48)
Positive_regulation (raise) of advance rent
2) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
I was able to raise sufficient advance rent by working very hard … I work all day at the store … so also is my husband, we had no choice but to do that in order to raise enough money for our advance rent…now we are focused on saving some money as we have only a year left before the landlord will start asking for a new rent contract…(F, 48)
Positive_regulation (sufficient) of advance rent
3) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
My wife and I have four children, so we needed at least a two bedroom rental space… In the end I have to pay my landlord an advance rent of ¢5.6 million which he used to complete the rooms we are now living in…(M, 41)
Positive_regulation (pay) of advance rent
4) Confidence 0.31 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
Blood tests showed elevated homocysteine levels, and coagulation studies revealed a homozygous C677T mutation and a heterozygous A1298C mutation of the methylenetetrahydrofolate reductase (MTHFR) gene.
Positive_regulation (homozygous) of mutation (C677T) in Blood
5) Confidence 0.09 Published 2008 Journal Genet. Test. Section Abstract Doc Link 18666857 Disease Relevance 0.72 Pain Relevance 0.09
Thrombophilia workup revealed prothrombin G20210A mutation (heterozygous), C677T mutation of methylenetetrahydrofolate reductase gene (homozygous), elevated level of lipoprotein (a), and high level of coagulation factor VIII.
Positive_regulation (revealed) of mutation (G20210A) associated with thrombophilia
6) Confidence 0.06 Published 2008 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 18160613 Disease Relevance 0.84 Pain Relevance 0.17
Finally, transcripts encoding the oxidative enzymes ALOX15B lipoxygenase [84] and cytochrome P450 epoxygenase family members [85], involved in the arachidonic acid metabolic pathway, are also significantly increased in the DSS-gene signature, also reflecting activation of those sub-pathways during DSS.
Positive_regulation (increased) of transcripts associated with dengue hemorrhagic fever
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.03 Pain Relevance 0.16
Interestingly, TPH2a 1234 editing (Figure 2C) was found elevated by 20% in transcripts obtained from the amygdala of drug abuse and suicide victims compared to controls (Table S4).
Positive_regulation (elevated) of transcripts in amygdala associated with suicidal behaviour, drug abuse and amygdala
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.34 Pain Relevance 0.19
Here we undertook to establish a new technique – denaturing high-performance liquid chromatography (DHPLC) – for accurately genotyping the two different mutational events resulting in the R122H mutation.
Positive_regulation (resulting) of mutation (R122H)
9) Confidence 0.01 Published 2001 Journal BMC Genet Section Body Doc Link PMC60523 Disease Relevance 0.32 Pain Relevance 0.09
DHPLC could readily discriminate the two known different mutational events resulting in the R122H mutation.
Positive_regulation (resulting) of mutation (R122H)
10) Confidence 0.01 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC60523 Disease Relevance 0.38 Pain Relevance 0
We therefore tested a molecular clock, using phylogenetic likelihood ratio tests [45], to ask whether the 68-bp region is evolving rapidly due to an elevated mutation rate.
Spec (whether) Positive_regulation (elevated) of mutation
11) Confidence 0.01 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1283535 Disease Relevance 0 Pain Relevance 0
Since almost all available treatment options had been administrated and high levels of H19 RNA transcripts were detected, she was offered a compassionate treatment with DTA-H19.
Positive_regulation (levels) of transcripts
12) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.88 Pain Relevance 0.14
The results for the "ribosome" pathway, in contrast, suggest a significant upregulation of the transcripts for the component genes of this pathway in the obese subjects, even after adjustment for erythrocyte-specific gene expression.
Positive_regulation (upregulation) of transcripts in erythrocyte associated with obesity
13) Confidence 0.01 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 0.65 Pain Relevance 0
An additional 113 transcripts were significantly changed in Groups I–II only; 44 transcripts, including FIBP, VTN, STOM, ICAM1, SEMA3B, RARG, RARA, were increased, and 68 transcripts, including APOL1, CALM1, CALM2, CAMK2B, GNB2L1, HINT1, RAB9A, CHEK1, PPP2CA and NFKBIA, were decreased.
Positive_regulation (increased) of transcripts
14) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.18 Pain Relevance 0.09
Also increased were transcripts encoding adaptins and an adaptin kinase (AP1M2, AP2A1, AP4B1, AAK1) associated with clathrin-coated vesicle endocytosis at the plasma membrane and in transport between the Golgi apparatus and the endosomal system.
Positive_regulation (increased) of transcripts in plasma
15) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.12 Pain Relevance 0.09
GAP scores did not reach significance for any of transcripts identified to be increased or deceased in drug abuse cases (Table 3, Table S2).


Positive_regulation (increased) of transcripts associated with drug abuse
16) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 1.57 Pain Relevance 0.42
Of particular note were increases in the apoliprotein L (APOL) transcripts, for which the increased expression of APOL2 was validated by QPCR (Fig. 3).
Positive_regulation (increases) of transcripts
17) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.10
Transcripts involved in various aspects of Golgi/ER function (YIPF5, GCC1, COG4, COPZ1, VPS37C, LEPREL1, CPVL, SEMA3B) were increased.
Positive_regulation (increased) of Transcripts
18) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.13 Pain Relevance 0.12
While transcripts encoding lysosomal enzymes (CTSD, DPP7) were increased, transcripts encoding proteins involved in synaptic vesicular trafficking (RIMBP2, ARL6IP4), transport from the late endosome to the lysosome (ASGR2, RAB9A), and a marker of cholesterol- and sphingolipid-rich lipid raft membrane microdomains involved in clathrin-independent endocytosis (FLOT1) were all decreased.


Positive_regulation (increased) of transcripts
19) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.12 Pain Relevance 0.03
To select transcripts which were similarly changed in the groups defined by toxicology described above and also in all 34 Group I–II cases, transcripts with average p-values ?
Positive_regulation (changed) of transcripts
20) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.15 Pain Relevance 0.17

General Comments

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