INT148704

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.30
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, TNFRSF1A) extracellular region (TNF, TNFRSF1A) plasma membrane (TNF, TNFRSF1A)
signal transduction (TNF) nucleus (TNFRSF1A) intracellular (TNF)
Anatomy Link Frequency
somatic cell 1
cartilage 1
TNF (Homo sapiens)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 100.00 Very High Very High Very High
Inflammation 27 99.46 Very High Very High Very High
antagonist 9 97.68 Very High Very High Very High
Osteoarthritis 37 97.52 Very High Very High Very High
cytokine 9 96.24 Very High Very High Very High
Inflammatory response 2 94.04 High High
Infliximab 11 87.28 High High
Etanercept 252 86.48 High High
spinal inflammation 60 77.80 Quite High
Adalimumab 2 77.36 Quite High
Disease Link Frequency Relevance Heat
Injury 2 100.00 Very High Very High Very High
Disease 50 99.92 Very High Very High Very High
INFLAMMATION 24 99.46 Very High Very High Very High
Hypercalcemia 1 98.16 Very High Very High Very High
Knee Osteoarthritis 36 97.52 Very High Very High Very High
Acute-phase Reaction 1 92.56 High High
Cancer 10 90.88 High High
Necrosis 9 90.44 High High
Adhesions 6 90.08 High High
Osteoarthritis 12 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF interacts with two different receptors, designated TNFR1 and TNFR2, which are differentially expressed on cells and tissues and initiate both distinct and overlapping signal transduction pathways.
TNF Binding (interacts) of TNFR1
1) Confidence 0.44 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18161752 Disease Relevance 0.86 Pain Relevance 0.15
Monomers of the extracellular portion of the TNFRs naturally cleaved from the cell surface are termed soluble TNF receptors (sTNFR). sTNFRs bind with high affinity to circulating TNF and act as natural antagonists to TNF preventing the TNF molecules from binding to cell-bound receptors.
TNF Binding (bind) of TNFR associated with antagonist
2) Confidence 0.39 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936291 Disease Relevance 0.34 Pain Relevance 0.39
Monomers of the extracellular portion of the TNFRs naturally cleaved from the cell surface are termed soluble TNF receptors (sTNFR). sTNFRs bind with high affinity to circulating TNF and act as natural antagonists to TNF preventing the TNF molecules from binding to cell-bound receptors.
TNF Binding (bind) of TNFR associated with antagonist
3) Confidence 0.39 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936291 Disease Relevance 0.34 Pain Relevance 0.39
TNF-alpha plays a crucial role in inducing tissue injury and by interacting with p55 TNF-alpha receptor contributes to focal loss of cartilage in OA [11,13].
TNF-alpha Binding (interacting) of p55 in cartilage associated with injury and osteoarthritis
4) Confidence 0.21 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.64 Pain Relevance 0.27
This inflammatory pathway is initiated when TNF is cleaved from the cell surface by a specific metalloproteinase and binds to its two receptors, TNFR-55 and TNFR-75, found in both soluble forms and on somatic cell surfaces.
TNF Binding (binds) of TNFR-55 in somatic cell associated with inflammation and metalloproteinase
5) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721344 Disease Relevance 1.12 Pain Relevance 0.89

General Comments

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