INT148710

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCN1) transmembrane transport (HCN1)
HCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
HCN1 60 100.00 Very High Very High Very High
Opioid 2 98.10 Very High Very High Very High
Potency 4 97.44 Very High Very High Very High
hCN2 8 78.92 Quite High
addiction 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low
Myocardial Infarction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The block of HCN1 for all compounds was voltage-dependent, being relieved at more negative potentials.
Negative_regulation (block) of HCN1 associated with hcn1
1) Confidence 0.43 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.48
Two blockers known for their activity at opioid/Ca(2+) channels and K(+) channels, loperamide and CP-339,818 (respectively), are described to block HCN1 more potently than HCN4.
Negative_regulation (block) of HCN1 associated with hcn1 and opioid
2) Confidence 0.38 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.45
Though we have identified key residues that determine ZD7288 block of HCN1 channels and energetically quantified their interactions, the nature of their side chain interactions with ZD7288 remains to be explored.
Negative_regulation (block) of HCN1 associated with hcn1
3) Confidence 0.34 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.16

General Comments

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