INT148714

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.53
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCN1) transmembrane transport (HCN1)
HCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
HCN1 99 100.00 Very High Very High Very High
Potency 2 100.00 Very High Very High Very High
Opioid 1 83.48 Quite High
hCN2 16 21.80 Low Low
addiction 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 4 79.84 Quite High
Hypertension 2 64.64 Quite High
Hypertrophy 2 63.92 Quite High
Myocardial Infarction 2 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For both HCN1 and HCN4, ZD7288 was most sensitive in lower Cl(-) solutions, while the potency of loperamide was not affected by the differing solutions.
Neg (not) Regulation (affected) of HCN1 associated with hcn1 and potency
1) Confidence 0.45 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.50
Of note, the HCN1 isoform examined in the present study is the least sensitive to cAMP among HCN1–4.
Regulation (sensitive) of HCN1-4 associated with hcn1
2) Confidence 0.36 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0.26 Pain Relevance 0.26
Of note, the HCN1 isoform examined in the present study is the least sensitive to cAMP among HCN1–4.
Regulation (sensitive) of HCN1 associated with hcn1
3) Confidence 0.32 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0.27 Pain Relevance 0.26

General Comments

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