INT148715

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.29
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCN1) transmembrane transport (HCN1)
Anatomy Link Frequency
pore 1
brain 1
embryonic kidney 1
HCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
HCN1 198 100.00 Very High Very High Very High
Potency 4 92.32 High High
Opioid 2 91.28 High High
Pain 1 89.60 High High
hCN2 32 74.92 Quite High
addiction 4 5.00 Very Low Very Low Very Low
local anesthetic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 10 100.00 Very High Very High Very High
Fatigue 1 93.12 High High
Weight Loss 1 92.40 High High
Pain 1 89.60 High High
Hepatocellular Cancer 4 86.84 High High
Cancer 1 84.56 Quite High
Heart Rate Under Development 8 42.76 Quite Low
Hypertension 4 27.56 Quite Low
Hypertrophy 4 26.84 Quite Low
Myocardial Infarction 4 26.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a new IonWorks HT electrophysiology assay with human HCN1 and HCN4 expressed stably in cell lines, four HCN channel blockers are characterized.
Gene_expression (expressed) of HCN1 associated with hcn1
1) Confidence 0.78 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.34
The voltage-dependent, Cl(-) dependent, HCN1 preferring compounds described here elaborate on the current known pharmacology of HCN channels and may help provide novel tools and chemical starting points for the investigation of HCN channel function in natively expressing systems.
Gene_expression (dependent) of HCN1 associated with hcn1
2) Confidence 0.67 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18162181 Disease Relevance 0 Pain Relevance 0.46
For identifying HCN1-expressing cells, the channel plasmid was cotransfected with pCI-green fluorescent protein (GFP) with a ratio of 10:1.
Gene_expression (expressing) of HCN1 associated with hcn1
3) Confidence 0.63 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.26
Molecular biology and heterologous expression Murine HCN1 cDNA was cloned from mouse brain RNA [27] and subcloned into the mammalian expression vector pCI (Promega, Madison, WI, USA).
Gene_expression (expression) of HCN1 in brain associated with hcn1
4) Confidence 0.54 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.31
In summary, we conclude that pore residues C347, F378, and V379 of HCN1 channels are crucial for ZD7288 block.
Gene_expression (channels) of HCN1 in pore associated with hcn1
5) Confidence 0.54 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.22
HCN1 channels were transiently expressed in human embryonic kidney 293 cells (HEK293) using Lipofectamine Plus 2000 (Invitrogen, Carlsbad, CA, USA).
Gene_expression (expressed) of HCN1 in embryonic kidney associated with hcn1
6) Confidence 0.47 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.30
With the exception of gallbladder HAC, there was a male predominance (M:F = 2.4:1).
Neg (exception) Gene_expression (exception) of HAC associated with adenocarcinoma
7) Confidence 0.12 Published 2010 Journal Onkologie Section Abstract Doc Link 20502062 Disease Relevance 1.29 Pain Relevance 0.09

General Comments

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