INT14872

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Context Info
Confidence 0.55
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 12.45
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TGFB3) aging (TGFB3) extracellular region (TGFB3)
plasma membrane (TGFB3) nucleus (TGFB3) embryo development (TGFB3)
Anatomy Link Frequency
pancreas 3
neurons 2
joint 1
exocrine pancreas 1
endometrium 1
TGFB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 32 98.88 Very High Very High Very High
cytokine 8 96.92 Very High Very High Very High
Snapping jaw 5 96.56 Very High Very High Very High
fibrosis 5 95.64 Very High Very High Very High
endometriosis 4 83.36 Quite High
Pain 4 83.16 Quite High
Inflammation 13 82.80 Quite High
Neuropeptide 2 80.00 Quite High
medulla 4 78.08 Quite High
cerebral cortex 2 72.40 Quite High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 230 100.00 Very High Very High Very High
Prostate Cancer 90 100.00 Very High Very High Very High
Pancreatitis 35 98.88 Very High Very High Very High
Pancreatic Cancer 30 98.44 Very High Very High Very High
Cardiomyopathy 13 98.12 Very High Very High Very High
Adenocarcinoma 5 96.56 Very High Very High Very High
Temporomandibular Joint Syndrome 5 96.56 Very High Very High Very High
Fibrosis 5 95.64 Very High Very High Very High
Frailty 2 95.24 Very High Very High Very High
Malocclusion 1 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, because of high postmenstrual TGF-beta3 levels, we suppose that it might participate in scarless postmenstrual regeneration of endometrium.
Gene_expression (levels) of TGF-beta3 in endometrium
1) Confidence 0.55 Published 2010 Journal Hum. Reprod. Section Abstract Doc Link 19892717 Disease Relevance 0.64 Pain Relevance 0.25
Those expressed extracellularly and with an average expression level at least three-fold greater in BPH RNA pools than in the prostate cancer RNA pools included: CDH13, CHRNB1, COL4A5, EFEMP2, EMP3, F10 (16-fold), FGF2, FGFBP1 (10-fold), IGF1, IGF2 (18-fold), LIPG, RARB, SGCA, SGCD, TGFB1, TGFB3 (14-fold), TGFBR2 and TIMP2 of the “high in BPH, moderate in prostate cancer” group; SMOC1 (26-fold) in the “high in BPH, low in prostate cancer” group; and SCGB3A1 (15-fold) and SCGB1A1 (14-fold) in the “moderate in BPH, low in prostate cancer” group.


Gene_expression (expressed) of TGFB3 associated with benign prostatic hypertrophy and prostate cancer
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 2.54 Pain Relevance 0
TGF-beta2 and TGF-beta3 expressions were observed in ductal structures, sometimes even in sites where no or few myofibroblasts were seen.
Gene_expression (expressions) of TGF-beta3
3) Confidence 0.42 Published 2006 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 16519564 Disease Relevance 0.06 Pain Relevance 0
In the normal hamster pancreas, TGF-alpha was overexpressed in the alpha-cells but not in any other islet cells.
Neg (not) Gene_expression (overexpressed) of TGF-alpha in pancreas
4) Confidence 0.28 Published 1995 Journal Teratog., Carcinog. Mutagen. Section Abstract Doc Link 8867879 Disease Relevance 0.60 Pain Relevance 0.14
Both TGF-alpha and EGFR were marginally detectable in the exocrine pancreas and in induced pancreatic lesions.
Gene_expression (detectable) of TGF-alpha in exocrine pancreas
5) Confidence 0.28 Published 1995 Journal Teratog., Carcinog. Mutagen. Section Abstract Doc Link 8867879 Disease Relevance 0.57 Pain Relevance 0.13
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (expressed) of TGF-alpha in pancreas associated with pancreatic cancer
6) Confidence 0.26 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.75 Pain Relevance 0.33
There is in vitro evidence that simultaneous overproduction of one of its ligands, transforming growth factor alpha (TGF-alpha), might result in an autocrine loop with an increased proliferation signal.
Gene_expression (overproduction) of TGF-alpha
7) Confidence 0.23 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.54 Pain Relevance 0.16
We analysed by immunocytochemical staining a retrospective series of human pancreatic cancers, chronic pancreatitis, and normal fetal and adult pancreatic tissues for the presence of TGF-alpha and epidermal growth factor (EGF).
Gene_expression (presence) of TGF-alpha associated with pancreatic cancer and chronic pancreatitis
8) Confidence 0.23 Published 1991 Journal J. Pathol. Section Abstract Doc Link 1707959 Disease Relevance 0.68 Pain Relevance 0.19
The EGF receptor, EGF and TGF-alpha are expressed in the normal human pancreas, and are over-expressed in human pancreatic cancer.
Gene_expression (expressed) of TGF-alpha in pancreas associated with pancreatic cancer
9) Confidence 0.22 Published 1994 Journal Int. J. Cancer Section Abstract Doc Link 8314343 Disease Relevance 0.75 Pain Relevance 0.33
These are EMP3, FGF2, FGFBP1, IGF1, IGF2, TGFB3, TGFBR2, and TIMP2.
Gene_expression (These) of TGFB3
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.71 Pain Relevance 0.03
In this communication, we demonstrate that adult mammalian brain neurons express transforming growth factor-alpha (TGF-alpha).
Gene_expression (express) of TGF-alpha in neurons
11) Confidence 0.10 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2645281 Disease Relevance 0 Pain Relevance 0.10
These studies indicate that the normal mammalian brain neurons express TGF-alpha.
Gene_expression (express) of TGF-alpha in neurons
12) Confidence 0.10 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2645281 Disease Relevance 0.09 Pain Relevance 0.14
The causative gene in ARVD1 is TGFB3, ARVD2 is RYR2, in ARVD5 is LAMR1, in ARVD8 DSP and in ARVD9 PKP2, in ARVD10DSG2, and in ARVD11 DSC2.
Gene_expression (is) of TGFB3
13) Confidence 0.06 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 1.86 Pain Relevance 0.03
Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation.
Gene_expression (expression) of TGF alpha associated with adenocarcinoma
14) Confidence 0.03 Published 2010 Journal Exp. Anim. Section Abstract Doc Link 20660988 Disease Relevance 0.94 Pain Relevance 0.46
TGF-beta3 was not detected in any joint sample.
Neg (not) Gene_expression (detected) of TGF-beta3 in joint
15) Confidence 0.01 Published 2006 Journal J Vet Dent Section Abstract Doc Link 16878760 Disease Relevance 0.74 Pain Relevance 0.66
In contrast, the levels of TGF-beta3 and receptors I and II remained unaffected or slighty modified by the compound.
Gene_expression (levels) of TGF-beta3
16) Confidence 0.00 Published 1999 Journal Osteoarthr. Cartil. Section Body Doc Link 10329300 Disease Relevance 0 Pain Relevance 0

General Comments

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