INT148721

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.78
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD1) cytosol (PSMD1) nucleoplasm (PSMD1)
small molecule metabolic process (PSMD1) cellular nitrogen compound metabolic process (PSMD1)
Anatomy Link Frequency
nerve 1
internal 1
PSMD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 51 100.00 Very High Very High Very High
Pain 34 99.76 Very High Very High Very High
metalloproteinase 56 99.04 Very High Very High Very High
Hypoesthesia 2 96.36 Very High Very High Very High
abdominal pain 2 91.00 High High
Bioavailability 2 85.56 High High
potassium channel 6 79.12 Quite High
alcohol 24 77.76 Quite High
cva 3 73.04 Quite High
backache 6 68.32 Quite High
Disease Link Frequency Relevance Heat
Pain 37 99.76 Very High Very High Very High
Obesity 20 99.38 Very High Very High Very High
Hypesthesia 2 96.36 Very High Very High Very High
Metastasis 11 96.28 Very High Very High Very High
Stomach Cancer 3 94.04 High High
Disease 48 93.00 High High
Infection 24 92.24 High High
Cardiovascular Disease 4 91.48 High High
Sprains And Strains 37 91.24 High High
Abdominal Pain 2 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The substitution of Tyr318 to Phe decreased kcat by two orders of magnitude without altering the binding affinity of substrate, or of a competitive hydroxamate inhibitor designed to interact with S1 and S2 subsites.
S1 Binding (interact) of
1) Confidence 0.31 Published 2008 Journal Biol. Chem. Section Abstract Doc Link 18163885 Disease Relevance 0.17 Pain Relevance 0.08
Alternatively, oscillations from S1 could propagate to M1, and thence to the periphery (Figure 7, Pathway 2).
S1 Binding (oscillations) of associated with primary somatosensory cortex
2) Confidence 0.27 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0.26
Following this strategy, we identified a series of SNPs in which the biochemical properties of the associated metabolites support the previously reported associations with their clinical outcomes (Tables 1 and S1; Datasets S1 and S2).
S1 Binding (associations) of
3) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581785 Disease Relevance 0.29 Pain Relevance 0
Consider three associated SNPs, S1, S2, and S3, each with two alleles denoted by 1 and 0.
S1 Binding (associated) of
4) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2422840 Disease Relevance 0 Pain Relevance 0
Following this strategy, we identified a series of SNPs in which the biochemical properties of the associated metabolites support the previously reported associations with their clinical outcomes (Tables 1 and S1; Datasets S1 and S2).
S1 Binding (associations) of
5) Confidence 0.15 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581785 Disease Relevance 0.29 Pain Relevance 0
Neurologically, L5 and S1 nerve roots impairment was indicated.
S1 Neg (impairment) Binding (impairment) of in nerve
6) Confidence 0.14 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948130 Disease Relevance 1.10 Pain Relevance 0.79
In the age-adjusted analyses (Table 3), none of the analyzed determinants were associated with Modic type I changes, whereas both weight-related factors (BMI and waist circumference) were associated with type II changes at L5-S1 when type II changes were included exclusively (ORs 1.42 and 1.48, respectively).
L5-S1 Binding (associated) of associated with obesity
7) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2373785 Disease Relevance 0.32 Pain Relevance 0.04
Furthermore, changes located at L5-S1 and Modic type I lesions may be more likely to be associated with pain symptoms than other types of Modic changes or changes located at other lumbar levels [17].
L5-S1 Spec (likely) Binding (associated) of associated with pain
8) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2373785 Disease Relevance 0.52 Pain Relevance 0.22
Combined therapy with S-1 and CPT-11 (IRIS regimen) was performed from August as the first-line therapy.
S-1 Binding (therapy) of
9) Confidence 0.12 Published 2008 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 19106523 Disease Relevance 0.83 Pain Relevance 0.09
As can be seen from the differences between the numbers of reads that could be classified down to genus level (153 in these samples, see Table S1), and the number of detected phylotypes/species (?
S1 Binding (see) of
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725325 Disease Relevance 0.09 Pain Relevance 0
Nevertheless, animals in the vicinity of S1, S2, and S3, were found to be infected (5/7, 5/8, and 3/10 animals, respectively).
S1 Binding (vicinity) of
11) Confidence 0.05 Published 2007 Journal Emerging Infectious Diseases Section Body Doc Link PMC2878230 Disease Relevance 1.17 Pain Relevance 0.04
However, screening of MMPIs from marine organisms that specifically bind to the S1?
S1 Binding (bind) of
12) Confidence 0.05 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0 Pain Relevance 0.17
It has been suggested that: (i) voltage-gating domains have a large amount of internal flexibility compared with the pore domains, (ii) the V-paddle is situated on the periphery of the V-domain with some cationic sidechains interacting with anionic elements of adjacent subunits S1, S2 and S3; (iii) S2 and S3 are situated more proximal than V-paddle to the P-domain, and (iv) some S4 arginine residues interact in a critical fashion with the lipid membrane [2], [4], [16], [17], [18], [19], [20].
S1 Binding (interacting) of in internal
13) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766034 Disease Relevance 0 Pain Relevance 0.07
Four subsites on the acyl side of the cleaved peptide bond, named S4, S3, S2, and S1, bind the peptide amino acids P4, P3, P2, and P1.
S1 Binding (bind) of
14) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0

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