INT148756

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.83
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
plasma 2
blood 1
fat 1
adipose tissue 1
ovary 1
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 99.40 Very High Very High Very High
Inflammation 57 99.20 Very High Very High Very High
agonist 21 95.24 Very High Very High Very High
tolerance 80 94.68 High High
Inflammatory response 4 91.00 High High
Bioavailability 3 83.76 Quite High
qutenza 1 72.32 Quite High
Potency 3 29.68 Quite Low
alcohol 1 10.60 Low Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 34 99.88 Very High Very High Very High
Diabetes Mellitus 190 99.72 Very High Very High Very High
Obesity 376 99.62 Very High Very High Very High
Polycystic Ovary Syndrome 2 99.32 Very High Very High Very High
INFLAMMATION 66 99.20 Very High Very High Very High
Insulin Resistance 89 98.78 Very High Very High Very High
Targeted Disruption 34 97.44 Very High Very High Very High
Body Weight 36 96.84 Very High Very High Very High
Atherosclerotic Plaque 3 95.20 Very High Very High Very High
Impaired Glucose Tolerance 79 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The compound 7 alone did not show a statistically significant effect on the plasma adiponectin level in KK-A(y)/Ta mice, while 1% 7 in the diets significantly lowered the blood glucose and triglyceride levels and 0.3% 7 mixed with DHA oil in the diets significantly increased the adiponectin level as compared with the control.
Regulation (effect) of adiponectin in blood
1) Confidence 0.60 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.06 Pain Relevance 0.19
However, despite favourable effects on the insulin-sensitising adipokine adiponectin in genetic models of 11?
Regulation (effects) of adiponectin
2) Confidence 0.48 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.26 Pain Relevance 0.15
Effect of BVT116429 treatment on adiponectin in vivo and in vitro
Regulation (Effect) of adiponectin
3) Confidence 0.48 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.43 Pain Relevance 0
Analysis of the plasma samples showed that BVT2733 had no significant effect on adiponectin concentrations (Fig. 8A).
Neg (no) Regulation (effect) of adiponectin in plasma
4) Confidence 0.35 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.27 Pain Relevance 0
in the control of glucose homeostasis expands beyond its primary action in adipose tissue, and involves the regulation of adipocytokine production such as adiponectin, leptin, and resistin [19]–[21].
Regulation (regulation) of adiponectin in adipose tissue associated with obesity
5) Confidence 0.34 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.97 Pain Relevance 0.15
As insulin resistance in response to obesity and high fat feeding has been demonstrated to arise from increased concentrations of local and circulating pro-inflammatory cytokines [21] and from a reduction of circulating adiponectin concentrations [22], [23], we determined these parameters in control- and IR?
Regulation (circulating) of adiponectin in fat associated with inflammation, obesity, insulin resistance and cytokine
6) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.91 Pain Relevance 0.17
Since it has been suggested that insulin resistance has an important role in etiology of type 2 DM and CVD, the effect of adiponectin polymorphism on CVD risk factors could be confounded by insulin resistance.
Regulation (effect) of adiponectin associated with cardiovascular disease, diabetes mellitus and insulin resistance
7) Confidence 0.24 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 1.37 Pain Relevance 0
There is also conflicting data on the influence of RT on adiponectin concentrations; some have reported no change [79, 116, 122] while others have reported increases [119, 120].
Regulation (influence) of adiponectin
8) Confidence 0.15 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.43 Pain Relevance 0
Also the association between Pro12Ala and adiponectin plasma levels seems controversial: in the Japanese population Ala12 allele is associated with reduced serum adiponectin levels [94, 96] whereas no significant effect of this polymorphism on serum adiponectin was observed in polycystic ovary syndrome, healthy women, and in Asian Indians [98, 101].
Regulation (effect) of adiponectin in ovary associated with polycystic ovary syndrome
9) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.80 Pain Relevance 0
This SNP has been also associated to altered plasma levels of LPL, leptin, adiponectin, and resistin.
Regulation (altered) of adiponectin in plasma
10) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 1.33 Pain Relevance 0

General Comments

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