INT148779

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Usf1, Calca) aging (Calca) intracellular (Calca)
enzyme binding (Usf1) DNA binding (Usf1) cytoplasm (Calca)
Anatomy Link Frequency
neurons 1
Usf1 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 8 100.00 Very High Very High Very High
Trigeminal ganglion neurons 4 99.56 Very High Very High Very High
Migraine 2 74.68 Quite High
Neuropeptide 1 68.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.40 Very High Very High Very High
Headache 2 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured rat trigeminal ganglion neurons, knockdown of either USF1 or USF2 reduced CGRP promoter activity.
USF1 Negative_regulation (reduced) of CGRP in neurons associated with ganglion cysts, calcitonin gene-related peptide and trigeminal ganglion neurons
1) Confidence 0.44 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18167349 Disease Relevance 0.40 Pain Relevance 0.59

General Comments

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