INT148780

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Usf2, Usf1) DNA binding (Usf2, Usf1) enzyme binding (Usf1)
Anatomy Link Frequency
neuronal 1
Usf2 (Rattus norvegicus)
Usf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 8 100.00 Very High Very High Very High
Trigeminal ganglion neurons 4 92.88 High High
Migraine 2 82.92 Quite High
Neuropeptide 1 77.04 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 92.00 High High
Headache 2 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the functional role of USF, we first demonstrated that small interfering RNAs directed against USF1 and USF2 reduced endogenous CGRP RNA and preferentially targeted the USF binding site at the 18-bp enhancer in the neuronal-like CA77 cell line.
USF2 Binding (targeted) of USF in neuronal associated with calcitonin gene-related peptide
1) Confidence 0.40 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18167349 Disease Relevance 0.41 Pain Relevance 0.62

General Comments

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