INT148784

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2) plasma membrane (Crhr2)
signal transducer activity (Crhr2)
Anatomy Link Frequency
neurons 1
Crhr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 8 98.72 Very High Very High Very High
Kinase C inhibitor 1 91.40 High High
antagonist 3 86.32 High High
spastic colon 1 75.00 Quite High
Pain 5 49.48 Quite Low
depression 1 35.84 Quite Low
Disease Link Frequency Relevance Heat
Stress 5 99.64 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 89.92 High High
Nociception 2 75.00 Quite High
Functional Bowel Disorder 1 75.00 Quite High
Pain 3 49.48 Quite Low
Anxiety Disorder 2 44.56 Quite Low
Depression 1 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that CRF has dual effects on amygdala neurons: CRF1 receptor-mediated PKA-dependent facilitation and CRF2 receptor-mediated inhibition.
Negative_regulation (inhibition) of CRF2 in neurons associated with amygdala
1) Confidence 0.40 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18171711 Disease Relevance 0.13 Pain Relevance 0.34
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Negative_regulation (reduced) of CRFR2 associated with stress
2) Confidence 0.27 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

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