INT148786

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Csk) plasma membrane (Csk) kinase activity (Csk)
cytoplasm (Csk)
Csk (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 10 98.64 Very High Very High Very High
Neuronal nitric oxide synthase 2 50.00 Quite Low
metalloproteinase 1 25.12 Quite Low
cytokine 2 20.24 Low Low
Pain 1 10.00 Low Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 122 97.64 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 96.48 Very High Very High Very High
B-cell Lymphoma 27 92.84 High High
Hodgkin's Disease 25 90.76 High High
Cancer 41 32.40 Quite Low
Colon Cancer 1 28.24 Quite Low
Mantle-cell Lymphoma 33 5.00 Very Low Very Low Very Low
Epstein-barr Virus 30 5.00 Very Low Very Low Very Low
Follicular Lymphoma 22 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the increase in the nNOS translocation by ATP was blocked by NMDA receptor antagonists and inhibitors of protein kinase A, protein kinase C, and Src kinase.
Negative_regulation (inhibitors) of Src kinase
1) Confidence 0.09 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity.
Negative_regulation (inhibition) of Src kinase associated with qutenza
2) Confidence 0.08 Published 2008 Journal Cancer Res. Section Title Doc Link 18172315 Disease Relevance 0 Pain Relevance 0.49
In vitro kinase assay and molecular modeling studies revealed that capsiate inhibits Src kinase activity via its preferential docking to the ATP-binding site of Src kinase.
Negative_regulation (inhibits) of Src kinase
3) Confidence 0.06 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18172315 Disease Relevance 0 Pain Relevance 0.13
This may soon change, since Yang at al. demonstrate that Src tyrosine kinase inhibition by dasatinib has antilymphoma effects because it inhibits cell growth in five of seven DLBCL cell lines.
Negative_regulation (inhibition) of Src tyrosine kinase associated with diffuse large b-cell lymphoma
4) Confidence 0.04 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.97 Pain Relevance 0

General Comments

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