INT148791

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
endothelial cells 2
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 17 82.76 Quite High
qutenza 5 75.00 Quite High
ischemia 5 31.60 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 86.76 High High
Cv Unclassified Under Development 23 85.52 High High
Thromboembolism 1 83.60 Quite High
Cancer 61 83.04 Quite High
Cv General 3 Under Development 14 82.76 Quite High
Coronary Heart Disease 8 71.44 Quite High
Thrombosis Related Under Development 2 67.92 Quite High
Hypertension 1 67.60 Quite High
Injury 2 60.24 Quite High
Cardiovascular Disorder Under Development 73 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, capsiate suppressed VEGF-induced activation of Src kinase and phosphorylation of its downstream substrates, such as p125(FAK) and VE-cadherin, without affecting autophosphorylation of the VEGF receptor KDR/Flk-1.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of VE-cadherin
1) Confidence 0.07 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18172315 Disease Relevance 0 Pain Relevance 0.14
For example, doxycycline targets the adherens junction in vascular endothelial cells by inducing total vascular endothelial-cadherin expression while decreasing vascular endothelial-cadherin phosphorylation (41).
Negative_regulation (decreasing) of Phosphorylation (phosphorylation) of endothelial-cadherin in endothelial cells
2) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 0.97 Pain Relevance 0.08

General Comments

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