INT1488

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.86
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
striatum 4
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 25 100.00 Very High Very High Very High
Dopamine 3 98.84 Very High Very High Very High
substance P 4 97.52 Very High Very High Very High
narcan 2 95.60 Very High Very High Very High
monoamine 2 92.32 High High
Endogenous opioid 1 79.52 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 7 100.00 Very High Very High Very High
Stress 2 75.00 Quite High
Body Weight 1 74.60 Quite High
Shock 1 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nalorphine (10(-5) M) reversed the inhibitory effect of met-enkephalin.
Negative_regulation (reversed) of Negative_regulation (effect) of enkephalin associated with enkephalin
1) Confidence 0.42 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206750 Disease Relevance 0 Pain Relevance 0.85
In addition, the combination of thiorphan and bestatin reversed the decreases of Met-enkephalin levels and the decreases of DA turnover in the striatum in conditioned suppression group.
Negative_regulation (reversed) of Negative_regulation (decreases) of Met-enkephalin in striatum associated with dopamine and enkephalin
2) Confidence 0.35 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3422094 Disease Relevance 0.19 Pain Relevance 0.54
The experimental data suggest that MPTP can affect the enkephalin system, while L-deprenyl can prevent MPTP-induced enkephalin depletion in the mice striatum bodies.
Negative_regulation (prevent) of Negative_regulation (depletion) of enkephalin in striatum associated with parkinson's disease and enkephalin
3) Confidence 0.09 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Abstract Doc Link 2118063 Disease Relevance 0.68 Pain Relevance 1.04

General Comments

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