INT14880

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 9.19
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
CAR 3
neurons 3
pyramidal neurons 2
dentate gyrus 2
cortex 2
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 5 99.98 Very High Very High Very High
Pyramidal cell 160 99.96 Very High Very High Very High
Action potential 12 99.90 Very High Very High Very High
Hippocampus 292 99.04 Very High Very High Very High
nMDA receptor 144 99.04 Very High Very High Very High
Desipramine 5 98.64 Very High Very High Very High
Inflammation 529 97.92 Very High Very High Very High
Chronic pancreatitis 7 97.88 Very High Very High Very High
cINOD 182 97.40 Very High Very High Very High
gABA 10 90.72 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 897 100.00 Very High Very High Very High
Targeted Disruption 15 99.84 Very High Very High Very High
Gallstones 3 99.80 Very High Very High Very High
Stress 8 99.64 Very High Very High Very High
Pancreatitis 11 99.44 Very High Very High Very High
Pancreatic Cancer 13 98.84 Very High Very High Very High
Cancer 26 98.80 Very High Very High Very High
Disease 111 98.28 Very High Very High Very High
INFLAMMATION 627 97.92 Very High Very High Very High
Carcinoma 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CA 19-9 and CAR-3 were, respectively, found to be increased in 85 per cent and 44 per cent of patients with pancreatic cancer, 28 per cent and 0 per cent with chronic pancreatitis and 72 per cent and 28 per cent with extra-pancreatic diseases.
Positive_regulation (increased) of CAR-3 in CAR associated with pancreatitis, pancreatic cancer and chronic pancreatitis
1) Confidence 0.65 Published 1990 Journal Dis. Markers Section Abstract Doc Link 1708317 Disease Relevance 1.04 Pain Relevance 0.27
Cholestasis seems to increase CAR-3 levels as well as those of other glycoproteic tumour markers, probably by interfering with the hepatic clearance of these substances.
Spec (probably) Positive_regulation (increase) of CAR-3 in CAR associated with cancer and gallstones
2) Confidence 0.65 Published 1991 Journal Oncology Section Abstract Doc Link 1987495 Disease Relevance 1.05 Pain Relevance 0.15
Serum levels of CAR-3 were significantly increased in 51% of the patients with pancreatic carcinomas, in 60% of patients with biliary tract carcinomas and in about 15% of the patients with carcinomas of the digestive apparatus.
Positive_regulation (increased) of CAR-3 in CAR associated with pancreatic cancer and carcinoma
3) Confidence 0.42 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 1.22 Pain Relevance 0.12
Since slow AHP currents are involved in accommodation of action potential discharge of CA1 pyramidal neurons [40], it is possible that the frequency of action potentials may increase in a mutant CA3 pyramidal neuron where NMDA receptor-AHP coupling is eliminated.
Spec (may) Positive_regulation (increase) of CA3 in pyramidal neuron associated with action potential, nmda receptor and pyramidal cell
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.28 Pain Relevance 0.54
High-frequency stimulation failed to induce slow hyperpolarizing currents in hippocampal CA3 pyramidal neurons of mutant mice
Neg (failed) Positive_regulation (induce) of CA3 in pyramidal neurons associated with pyramidal cell
5) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.36
Phase coupling of gamma oscillations between CA1 and CA3 increases during memory retrieval (Montgomery and Buzsaki, 2007), which occurs at different gamma frequencies than between CA1 and the enthorinal cortex (Colgin et al., 2009).
Positive_regulation (increases) of CA3 in cortex
6) Confidence 0.36 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.42 Pain Relevance 0.10
FLU up-regulated BDNF mRNA levels in the CA3 of TG animals while both FLU and DMI increased BDNF gene expression in the dentate gyrus (DG) of TG animals.
Positive_regulation (up-regulated) of CA3 in dentate gyrus associated with targeted disruption, desipramine and fluoxetine
7) Confidence 0.27 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555640 Disease Relevance 0.63 Pain Relevance 0.97
Expression levels of calpain tended to be increased in the cortex and CA3 of A?
Positive_regulation (increased) of CA3 in cortex
8) Confidence 0.25 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.09 Pain Relevance 0
(D): There was, however, increased neurogenesis in the DG, CA3, and CA1 regions of the dorsal intact hippocampus in activin A-treated animals (n = 10, gray bars), whereas (FS-288)-treated animals had no effect on neurogenesis (n = 10, black bars) compared to controls (n = 10, white bars).
Positive_regulation (increased) of CA3 in bars associated with hippocampus and neurodegenerative disease
9) Confidence 0.22 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.43 Pain Relevance 0.11
(F): Meanwhile, activin A infusion following PBS injection (n = 8, gray bars) increased the total neuron population 42 days later in the CA3 and CA1 compared to their respective vehicle-treated controls (n = 8, white bars).
Positive_regulation (increased) of CA3 in neuron
10) Confidence 0.17 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.25 Pain Relevance 0.03
We found that intraventricular infusion of activin A increased the number of newborn neurons in the dentate gyrus, CA3, and CA1 layers of the normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro.
Positive_regulation (increased) of CA3 in dentate gyrus associated with hippocampus and gliosis
11) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.66 Pain Relevance 0.16
Consistent with the role of activin A in regulating astrocyte proliferation after KA-induced neurodegeneration, infusion of FS-288 following KA injection resulted in a 94%, 187%, and 194% increase in the average number of proliferating astrocytes in the DG, CA3, and CA1 regions, respectively, but not in the neurogenic pPV, when compared to KA-injected animals that received no FS-288 (Fig. 3K).
Positive_regulation (increase) of CA3 in astrocytes
12) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.37 Pain Relevance 0.19
As expected, there was a 96%, 65%, and 234% increase in the average number of newly generated neurons in the DG, CA3, or CA1 regions of the hippocampus of animals that received activin A, compared to animals that received no activin A after a PBS injection.
Positive_regulation (increase) of CA3 in neurons associated with hippocampus
13) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.54 Pain Relevance 0.05
Furthermore, infusion of activin A alone increased the total neuron population in the CA3 and CA1 regions of the hippocampus 42 days later, even in the absence of previous cell loss (Fig. 2F).
Positive_regulation (increased) of CA3 in hippocampus associated with hippocampus
14) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.64 Pain Relevance 0.11
Indeed, the average number of newly generated neurons in the DG, CA3, and CA1 was increased by 547%, 371%, and 299%, respectively, in animals that received NSAIDs compared to the DG, CA3, and CA1 regions of KA-injected (FS-288)-treated animals that did not receive NSAIDs (Fig. 7G).
Positive_regulation (increased) of CA3 in neurons associated with cinod
15) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.96 Pain Relevance 0.55
Recently, Gailly et al. showed that the deletion of ClC-5 in mouse and human PT cells is associated with increased cell proliferation, oxidative stress and the specific induction of type III carbonic anhydrase [29].
Positive_regulation (induction) of type III carbonic anhydrase associated with stress
16) Confidence 0.15 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2964617 Disease Relevance 0.63 Pain Relevance 0

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