INT148804

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.37
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Diablo) mitochondrion (Diablo) cytoplasm (Diablo)
Diablo (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 26 100.00 Very High Very High Very High
imagery 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 36 100.00 Very High Very High Very High
Colon Cancer 8 98.52 Very High Very High Very High
Cancer 166 92.08 High High
Recurrence 12 86.60 High High
Myeloid Leukemia 6 85.04 High High
Colorectal Cancer 2 79.04 Quite High
Fibromyalgia 2 79.00 Quite High
INFLAMMATION 6 75.92 Quite High
Glioblastoma 12 72.16 Quite High
Hepatocellular Cancer 2 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Smac, in association with Direct Inhibitor of Apoptosis Binding Protein with low pI (Smac/DIABLO), promotes apoptosis via neutralization of inhibitor of apoptosis (IAP) proteins [82].
DIABLO Binding (association) of associated with apoptosis
1) Confidence 0.47 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 1.22 Pain Relevance 0
Smac, in association with Direct Inhibitor of Apoptosis Binding Protein with low pI (Smac/DIABLO), promotes apoptosis via neutralization of inhibitor of apoptosis (IAP) proteins [82].
Smac Binding (association) of associated with apoptosis
2) Confidence 0.35 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 1.22 Pain Relevance 0
In this study, we found that SMAC mediates NSAID-induced apoptosis through a feedback amplification mechanism involving interactions with inhibitor of apoptosis proteins, activation of caspase-3, and induction of cytosolic release of cytochrome c.
SMAC Binding (interactions) of associated with cinod and apoptosis
3) Confidence 0.14 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18172320 Disease Relevance 1.03 Pain Relevance 0.92
Together, these results suggest that SMAC is useful as a target for the development of more effective chemopreventive strategies and agents.
SMAC Binding (target) of
4) Confidence 0.11 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18172320 Disease Relevance 0.90 Pain Relevance 0.75

General Comments

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