INT14881

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Context Info
Confidence 0.73
First Reported 1988
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 49
Total Number 51
Disease Relevance 14.89
Pain Relevance 9.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
hippocampus 7
dentate gyrus 6
pyramidal cells 5
CAR 4
spikes 3
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1336 100.00 Very High Very High Very High
Pyramidal cell 1061 100.00 Very High Very High Very High
Hippocampus 596 100.00 Very High Very High Very High
Chronic pancreatitis 9 100.00 Very High Very High Very High
ketamine 64 99.84 Very High Very High Very High
Glutamate receptor 243 99.16 Very High Very High Very High
long-term potentiation 347 98.90 Very High Very High Very High
Inflammation 196 98.32 Very High Very High Very High
Glutamate 49 98.28 Very High Very High Very High
antagonist 78 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 150 100.00 Very High Very High Very High
Pancreatitis 14 100.00 Very High Very High Very High
Carcinoma 12 100.00 Very High Very High Very High
Sarcoma 3 99.92 Very High Very High Very High
Pancreatic Cancer 15 99.84 Very High Very High Very High
Neurodegenerative Disease 294 99.76 Very High Very High Very High
Melanoma 3 99.44 Very High Very High Very High
Targeted Disruption 367 98.88 Very High Very High Very High
Disease 148 98.68 Very High Very High Very High
Sprains And Strains 286 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAR-3 and CA 19-9 serum levels in pancreatic cancer: any differences between two epitopes of the same mucin-like glycoprotein?
Gene_expression (levels) of CAR-3 in CAR associated with pancreatic cancer
1) Confidence 0.73 Published 1990 Journal Dis. Markers Section Title Doc Link 1708317 Disease Relevance 1.00 Pain Relevance 0.22
The monoclonal antibody-defined CAR-3 antigen is a new carcinoma associated marker which is expressed on a mucin-like molecule.
Gene_expression (expressed) of CAR-3 in CAR associated with carcinoma
2) Confidence 0.71 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 0.87 Pain Relevance 0.09
CAR-3 values in samples from patients with chronic pancreatitis were constantly negative, as were samples from healthy donors.
Neg (negative) Gene_expression (negative) of CAR-3 in CAR associated with chronic pancreatitis
3) Confidence 0.61 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 1.41 Pain Relevance 0.26
Ablation of CA3 NMDA receptors in the mature brain also generated characteristic EEG spikes with large amplitudes
Gene_expression (receptors) of CA3 in spikes associated with nmda receptor
4) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.32 Pain Relevance 0.40
Since seizure is produced by synchronous firing of a population of neurons in the brain [38], it is possible that NMDA receptor ablation in the CA3 region may modify hippocampal network oscillations in vivo.
Gene_expression (ablation) of CA3 in brain associated with convulsion and nmda receptor
5) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.18 Pain Relevance 0.12
Pharmacological blockade of CA3 NMDA receptors enhanced the susceptibility to kainate-induced seizure
Gene_expression (receptors) of CA3 associated with convulsion and nmda receptor
6) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.54 Pain Relevance 0.35
The activity of single pyramidal neurons spreads to other CA3 neurons and this facilitates the rapid synchronization of action-potential firing in CA3 neurons [3].
Gene_expression (neurons) of CA3 in neurons associated with pyramidal cell
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.14 Pain Relevance 0.16
Morphology of AAV-EGFP infected CA3 neurons
Gene_expression (neurons) of CA3 in neurons
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.14 Pain Relevance 0.05
CSD analysis revealed the sink in the pyramidal cell layer of the CA3 region and the sources in neighboring stratum oriens (Fig. 8E, n?
Gene_expression (region) of CA3 in pyramidal cell associated with pyramidal cell
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.46 Pain Relevance 0.38
Serum levels of CAR-3 were significantly increased in 51% of the patients with pancreatic carcinomas, in 60% of patients with biliary tract carcinomas and in about 15% of the patients with carcinomas of the digestive apparatus.
Gene_expression (levels) of CAR-3 in CAR associated with pancreatic cancer and carcinoma
10) Confidence 0.55 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 1.15 Pain Relevance 0.12
We have evidence that inhibitory inputs to CA3 pyramidal neurons may be mainly mediated by ?
Gene_expression (pyramidal neurons) of CA3 in pyramidal neurons associated with pyramidal cell
11) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.12 Pain Relevance 0.39
Between mouse strains, oscillation frequency in CA1 showed similar differences as was the case for CA3 (NOD: 19.7?
Gene_expression (case) of CA3 associated with sprains and strains
12) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.24 Pain Relevance 0.37
In cell-attached recordings during carbachol-induced oscillations, the AP firing frequency of CA3 pyramidal cells was significantly higher in NOD (6.1?
Gene_expression (pyramidal cells) of CA3 in pyramidal cells associated with pyramidal cell
13) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.24 Pain Relevance 0.56
Mean spine density on basal dendrites of CA3 pyramidal cells was also comparable (n?
Gene_expression (pyramidal cells) of CA3 in pyramidal cells associated with pyramidal cell
14) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.05 Pain Relevance 0.15
1/GluR1, were comparable in the hippocampal CA3 region between the two genotypes (Fig. 4D and E).
Gene_expression (region) of CA3
15) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.15 Pain Relevance 0.14
The relative expression levels of the mRNAs in the hippocampal CA3 region were calculated using the ratio of the density in the CA3 region to that of the CA1 region, except that the GluR?
Gene_expression (region) of CA3
16) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0
Basic electrophysiological properties of CA3 pyramidal cells were indistinguishable between two genotypes (resting membrane potential: control, ?
Gene_expression (pyramidal cells) of CA3 in pyramidal cells associated with pyramidal cell
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.09 Pain Relevance 0.40
Golgi staining revealed no appreciable differences in dendritic arborization of CA3 pyramidal cells between control and mutant mice (Fig. 4G).
Gene_expression (pyramidal cells) of CA3 in pyramidal cells associated with pyramidal cell
18) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.13 Pain Relevance 0.28
1 protein was present in the CA3 region at P7, though the amount appeared to be decreased (Fig. 2D).
Gene_expression (region) of CA3
19) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.18
No such spike activity was detected in EEG records from the CA3 region of AAV-Cre-infected GluR?
Gene_expression (region) of CA3 in spike associated with glutamate receptor
20) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.49 Pain Relevance 0.40

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