INT14883

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 5.57
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
CAR 3
astrocyte 2
molecular layer 1
neuron 1
hilus 1
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 145 100.00 Very High Very High Very High
Hippocampus 173 99.96 Very High Very High Very High
Chronic pancreatitis 7 98.76 Very High Very High Very High
Pyramidal cell 162 94.08 High High
Central nervous system 64 90.28 High High
Inflammation 229 90.00 High High
long-term potentiation 2 89.56 High High
GABAergic 24 88.80 High High
nMDA receptor antagonist 8 85.00 Quite High
agonist 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 63 100.00 Very High Very High Very High
Hepatotoxicity 1 99.98 Very High Very High Very High
Sarcoma 1 99.92 Very High Very High Very High
Melanoma 1 99.44 Very High Very High Very High
Neurodegenerative Disease 386 99.14 Very High Very High Very High
Pancreatic Cancer 13 99.04 Very High Very High Very High
Pancreatitis 11 98.76 Very High Very High Very High
Gallstones 3 98.16 Very High Very High Very High
Breast Cancer 1 97.04 Very High Very High Very High
Cancer 14 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholestasis which can greatly influence a serum glycoproteic marker such as CA 19-9, was found also to affect, to a lesser extent, CAR-3, an epitope on the same mucin molecule.
Regulation (affect) of CAR-3 in CAR associated with gallstones
1) Confidence 0.58 Published 1990 Journal Dis. Markers Section Abstract Doc Link 1708317 Disease Relevance 0.97 Pain Relevance 0.20
A new tumour marker, CAR-3, was isolated using the monoclonal antibody technique and measured in the sera of 27 patients with pancreatic cancer, 25 chronic pancreatitis, 30 extra-pancreatic diseases and in that of 18 healthy controls in order (1) to evaluate the diagnostic role of CAR-3 in patients with pancreatic cancer and (2) to ascertain whether liver dysfunction influences CAR-3 serum levels.
Spec (whether) Regulation (influences) of CAR-3 in CAR associated with cancer, pancreatitis, pancreatic cancer, hepatotoxicity and chronic pancreatitis
2) Confidence 0.50 Published 1991 Journal Oncology Section Abstract Doc Link 1987495 Disease Relevance 1.08 Pain Relevance 0.18
One or combination of such NMDA receptor-mediated suppressive signals [34], [43]–[45], [58]–[60] might underlie the regulation of CA3 network excitability.
Spec (might) Regulation (regulation) of CA3 associated with nmda receptor
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.44
However, the power at the frequency that showed maximal power (peak power) in CA3 in each mouse strain was not different for the eight inbred strains (p?
Neg (not) Regulation (different) of CA3 associated with sprains and strains
4) Confidence 0.35 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.49 Pain Relevance 0.40
The number of Nissl-stained neuronal profile in areas CA3, CA1, the dentate hilus, and the dentate gyrus were counted in both the right and left hippocampus in horizontal sections for each animal by using four to five Nissl-stained sections that were ?
Regulation (left) of CA3 in hilus associated with hippocampus
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0 Pain Relevance 0.14
CAR-3 values in samples from patients with chronic pancreatitis were constantly negative, as were samples from healthy donors.
Regulation (values) of CAR-3 in CAR associated with chronic pancreatitis
6) Confidence 0.25 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 1.38 Pain Relevance 0.25
No staining was detected in the lacunosum-molecular layer in CA1, CA2 and CA3 (Figures 9b, 9c and 9d).
Regulation (molecular layer) of CA3 in molecular layer
7) Confidence 0.19 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.22 Pain Relevance 0.19
The difference in the neural wiring pattern such as the abundance of recurrent networks may underlie the different effects of NMDA receptor ablation in the hippocampal CA1 and CA3 regions on network activity.
Regulation (effects) of CA3 in neural associated with nmda receptor
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.06 Pain Relevance 0.61
S1), subsequent neurogenesis actually partly restored the total neuron populations in the CA3 and CA1 regions.
Regulation (populations) of CA3 in neuron associated with neurodegenerative disease
9) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.54 Pain Relevance 0.04
Infusion of activin A itself had no additional effect on astrocyte proliferation in the hippocampal DG, CA3, CA1, and pPV regions after KA injection (Fig. 3K).
Neg (no) Regulation (effect) of CA3 in astrocyte
10) Confidence 0.09 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.34 Pain Relevance 0.18
To determine whether activin A had a role in this process, we first assessed whether activin A regulated the number of proliferating astrocytes in the DG, CA3, CA1, and pPV regions [7, 24].
Spec (whether) Regulation (regulated) of CA3 in astrocytes
11) Confidence 0.09 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.48 Pain Relevance 0.13

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