INT14884

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Context Info
Confidence 0.25
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 20.37
Pain Relevance 26.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
lymphocytes 13
mononuclear phagocytes 5
neural 4
immune cells 4
conjunctiva 4
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 649 100.00 Very High Very High Very High
calcitonin gene related peptide 192 100.00 Very High Very High Very High
Morphine 63 100.00 Very High Very High Very High
Calcitonin gene-related peptide 38 100.00 Very High Very High Very High
pruritus 213 99.70 Very High Very High Very High
Inflammation 513 99.68 Very High Very High Very High
antagonist 298 99.40 Very High Very High Very High
tetrodotoxin 36 99.36 Very High Very High Very High
cytokine 151 99.16 Very High Very High Very High
Pain 45 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acid Reflux 36 99.92 Very High Very High Very High
Pruritus 259 99.70 Very High Very High Very High
INFLAMMATION 640 99.68 Very High Very High Very High
Endometriosis (extended) 1 99.46 Very High Very High Very High
Pain 56 99.16 Very High Very High Very High
Esophageal Disease 264 99.00 Very High Very High Very High
Neurogenic Inflammation 37 98.86 Very High Very High Very High
Eczema 15 98.80 Very High Very High Very High
Injury 80 98.12 Very High Very High Very High
Conjunctiva Disease 20 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, morphine induced SP receptor (NK-1R) expression in human lymphocytes.
Positive_regulation (induced) of Gene_expression (expression) of SP in lymphocytes associated with substance p and morphine
1) Confidence 0.25 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.08 Pain Relevance 1.36
Throughout the pulp, the expression of SP was found to be significantly increased with the progression of caries.
Positive_regulation (increased) of Gene_expression (expression) of SP associated with substance p
2) Confidence 0.25 Published 2000 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11153921 Disease Relevance 0.46 Pain Relevance 0.93
The specific morphine receptor antagonist (naltrexone) blocked morphine-induced SP expression in human mononuclear phagocytes, supporting the concept of authentic morphine receptor-mediated regulation.
Positive_regulation (induced) of Gene_expression (expression) of SP in mononuclear phagocytes associated with antagonist, substance p and morphine
3) Confidence 0.23 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.09 Pain Relevance 1.37
The specific morphine receptor antagonist (naltrexone) blocked morphine-induced SP expression in human mononuclear phagocytes, supporting the concept of authentic morphine receptor-mediated regulation.
Positive_regulation (-) of Gene_expression (expression) of SP in mononuclear phagocytes associated with antagonist, substance p and morphine
4) Confidence 0.23 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.09 Pain Relevance 1.37
Since SP modulates neurogenic inflammation and immunologic events, these data suggest that morphine-induced SP expression in cells of the immune system may be of importance in the pathogenesis of immune-mediated diseases, including neuroimmunologic diseases and AIDS.
Positive_regulation (-) of Gene_expression (expression) of SP in immune system associated with inflammation, acquired immune deficiency syndrome or hiv infection, disease, neurogenic inflammation, morphine and substance p
5) Confidence 0.20 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.38 Pain Relevance 1.30
Morphine up-regulated SP production in human mononuclear phagocytes and lymphocytes at both the mRNA and the protein level.
Positive_regulation (regulated) of Gene_expression (production) of SP in lymphocytes associated with substance p and morphine
6) Confidence 0.20 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.07 Pain Relevance 1.30
Since SP modulates neurogenic inflammation and immunologic events, these data suggest that morphine-induced SP expression in cells of the immune system may be of importance in the pathogenesis of immune-mediated diseases, including neuroimmunologic diseases and AIDS.
Positive_regulation (induced) of Gene_expression (expression) of SP in immune system associated with inflammation, acquired immune deficiency syndrome or hiv infection, disease, neurogenic inflammation, morphine and substance p
7) Confidence 0.20 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.38 Pain Relevance 1.30
Both dentitions showed significant increases in CGRP, SP, VIP and NPY expression with caries progression.
Positive_regulation (increases) of Gene_expression (expression) of SP in dentitions associated with substance p and calcitonin gene-related peptide
8) Confidence 0.19 Published 2002 Journal Arch. Oral Biol. Section Abstract Doc Link 12015218 Disease Relevance 0 Pain Relevance 0.81
In line with this hypothesis, an increase of SP tear and plasma levels and an altered VIP and SP expression in the conjunctiva have been described in patients with vernal keratoconjunctivitis (VKC), a severe ocular allergic disease mainly affecting young boys [23-25].
Positive_regulation (increase) of Gene_expression (expression) of SP in conjunctiva associated with conjunctiva disease, hypersensitivity, disease and substance p
9) Confidence 0.12 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.56 Pain Relevance 0.50
In line with this hypothesis, an increase of SP tear and plasma levels and an altered VIP and SP expression in the conjunctiva have been described in patients with vernal keratoconjunctivitis (VKC), a severe ocular allergic disease mainly affecting young boys [23-25].
Positive_regulation (increase) of Gene_expression (tear) of SP in conjunctiva associated with conjunctiva disease, hypersensitivity, disease and substance p
10) Confidence 0.11 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.54 Pain Relevance 0.49
SP and CGRP levels increased in mucosal tissue and in supernatant in response to HCl (Fig. 2 and 3) and the increases were abolished by the TRPV1 receptor antagonist 5'-iodoresinferratoxin (IRTX) or by neural block with tetrodotoxin, suggesting that TRPV1-induced production of SP and CGRP was neurally mediated.
Positive_regulation (mediated) of Gene_expression (production) of SP in neural associated with tetrodotoxin, calcitonin gene related peptide, antagonist and substance p
11) Confidence 0.08 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.83
Morphine up-regulated SP production in human mononuclear phagocytes and lymphocytes at both the mRNA and the protein level.
Positive_regulation (regulated) of in mononuclear phagocytes Gene_expression (production) of SP in lymphocytes associated with substance p and morphine
12) Confidence 0.07 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.07 Pain Relevance 1.30
SP and CGRP levels increased in mucosal tissue and in supernatant in response to HCl (Fig. 2 and 3) and the increases were abolished by the TRPV1 receptor antagonist 5'-iodoresinferratoxin (IRTX) or by neural block with tetrodotoxin, suggesting that TRPV1-induced production of SP and CGRP was neurally mediated.
Positive_regulation (mediated) of Gene_expression (production) of SP in neural associated with tetrodotoxin, calcitonin gene related peptide, antagonist and substance p
13) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.83
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Positive_regulation (activation) of Gene_expression (migration) of SP associated with inflammation and substance p
14) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.64
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Positive_regulation (induced) of Gene_expression (migration) of SP associated with inflammation and substance p
15) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.58 Pain Relevance 0.64
SP is known to be a chemoattractant and activator of lymphocytes, monocytes, mast cells and importantly neutrophils and eosinophils.66
Positive_regulation (activator) of Gene_expression (chemoattractant) of SP in lymphocytes associated with substance p
16) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.67 Pain Relevance 0.35
SP is known to be a chemoattractant and activator of lymphocytes, monocytes, mast cells and importantly neutrophils and eosinophils.66
Positive_regulation (activator) of Gene_expression (known) of SP in lymphocytes associated with substance p
17) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.67 Pain Relevance 0.35
We propose that acid in the lumen of the esophagus activates TRPV1 receptors causing the production and release of PAF, SP and CGRP that, in turn, may attract and activate immune cells contributing to inflammation and injury of the esophageal mucosa.
Positive_regulation (activate) of Gene_expression (production) of SP in immune cells associated with calcitonin gene related peptide, inflammation, injury and substance p
18) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.85 Pain Relevance 0.44
We propose that acid in the lumen of the esophagus activates TRPV1 receptors causing the production and release of PAF, SP and CGRP that, in turn, may attract and activate immune cells contributing to inflammation and injury of the esophageal mucosa.
Positive_regulation (causing) of Gene_expression (production) of SP in immune cells associated with calcitonin gene related peptide, inflammation, injury and substance p
19) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.84 Pain Relevance 0.43
is necessary to induce SP production (Fig. 1A), perhaps similar stimulation is necessary to induce the production of other neurotransmitters not found in the present study.
Positive_regulation (necessary) of Gene_expression (production) of SP associated with neurotransmitter and substance p
20) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.10 Pain Relevance 0.80

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